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Titolo:
Neural transplants: effects on startle responses in neonatally MSG-treatedrats
Autore:
Yang, FC; Connor, J; Patel, A; Doat, MM; Romero, MT;
Indirizzi:
SUNY Binghamton, Dept Psychol, Binghamton, NY 13902 USA SUNY Binghamton Binghamton NY USA 13902 Psychol, Binghamton, NY 13902 USA
Titolo Testata:
PHYSIOLOGY & BEHAVIOR
fascicolo: 3, volume: 69, anno: 2000,
pagine: 333 - 344
SICI:
0031-9384(200005)69:3<333:NTEOSR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; MONOSODIUM-L-GLUTAMATE; FEAR-POTENTIATED STARTLE; MESSENGER-RIBONUCLEIC-ACID; ACOUSTIC STARTLE; ARCUATE NUCLEUS; NEUROPEPTIDE-Y; PARAVENTRICULAR NUCLEUS; GONADOTROPIN-SECRETION; BEHAVIORAL-RESPONSES;
Keywords:
MSG; acoustic startle response; neural transplantation; arcuate nucleus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Romero, MT SUNY Binghamton, Dept Psychol, Binghamton, NY 13902 USA SUNY Binghamton Binghamton NY USA 13902 nghamton, NY 13902 USA
Citazione:
F.C. Yang et al., "Neural transplants: effects on startle responses in neonatally MSG-treatedrats", PHYSL BEHAV, 69(3), 2000, pp. 333-344

Abstract

Neonatal monosodium glutamate (MSG) treatment has been associated with disfunctions in stress responses. Therefore, the present study aimed at examining the acoustic startle response (ASR) in MSG-treated rats and the effectsof fetal neural transplantation. Male and female rats were given MSG (4 mg/g) or saline on alternate days from days 2-10 after birth. To determine whether fetal transplants could reverse behavioral impairments observed in MSG-treated rats, at 12 days of age MSG-treated rats received either arcuate nucleus (AN), cortical fetal grafts, or sham surgery into the third ventricle. ASR amplitude was measured at 35-40 days of age, and again in adulthood. MSG produced the expected decrease in the density of hypothalamic neuropeptide Y (NPY) and tyrosine hydroxylase (TH) in the AN area. Corticotropin-releasing factor (CRF) neurons/fibers were not affected by MSG. Pituitary atrophy was observed in all MSG rats. We report a permanent increase in the amplitude and reduction in short-term habituation of ASR in all MSG-treated rats. No effect was observed on long-term habituation in male rats. Cortical, but not AN tissue significantly reduced the magnitude of ASR in MSG animals. The results are discussed in terms of the central pathways mediating ASR, in particular hypothalamo-amygdala connections. It is considered that nonspecific factors mediate recovery produced by cortical tissue grafts, as observed in other models of neural transplantation. (C) 2000 Elsevier Science Inc. All rights reserved.

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Documento generato il 04/04/20 alle ore 12:22:18