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Titolo:
Immunological stress in rats induces bodily alterations in saline-treated conspecifics
Autore:
Fernandes, GA;
Indirizzi:
Univ Estadual Campinas, Fac Ciencias Med, Dept Clin Pathol Nucleo Med & Cirurgia Expt, BR-13083970 Campinas, SP, Brazil Univ Estadual Campinas Campinas SP Brazil BR-13083970 BCpinas, SP, Brazil
Titolo Testata:
PHYSIOLOGY & BEHAVIOR
fascicolo: 3, volume: 69, anno: 2000,
pagine: 221 - 230
SICI:
0031-9384(200005)69:3<221:ISIRIB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; PITUITARY-ADRENAL AXIS; SYMPATHETIC NERVOUS-SYSTEM; CELLULAR IMMUNE-RESPONSES; C-FOS EXPRESSION; LOCUS-COERULEUS; PLASMA-CORTICOSTERONE; HORMONE; NEUROENDOCRINE; NOREPINEPHRINE;
Keywords:
immune challenge; stress; conspecifics; hormones; gland weight; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Fernandes, GA Univ Estadual Campinas, Fac Ciencias Med, Dept Clin Pathol Nucleo Med & Cirurgia Expt, BR-13083970 Campinas, SP, Brazil Univ Estadual Campinas Campinas SP Brazil BR-13083970 BCzil
Citazione:
G.A. Fernandes, "Immunological stress in rats induces bodily alterations in saline-treated conspecifics", PHYSL BEHAV, 69(3), 2000, pp. 221-230

Abstract

This work was developed during an investigation on the neuroendocrine-immune interaction in rats immune challenged with sheep red blood cells (SRBC). The structures used for evaluating the immunological response was the direct plaque-forming cells (PFC). An inbred strain of rat was used to overcomethe problem of different timings in the peak humoral immune response. Normal rats were injected intraperitoneally with saline or SRBC and were killed0, 3, 4, 5, and 6 days later. Body and gland weights were recorded, and serum levels of corticosterone and prolactin were quantified by radioimmunoassay. The hormone levels and gland weights of the saline conspecifics and SRBC-treated rats were found to be similar. When new rats were housed in a separate room and treated with physiological saline, there were again no differences in the body and gland weights or the serum hormone levels between the two home cage control (HCC) groups of animals. Compared with Saline conspecifics and SRBC-treated groups, the HCC groups had higher body weights from the third to the sixth day of treatment and had lower gland weights in absolute and relative analysis (pituitary, thyroid, and adrenals) mainly on the fourth and fifth days; thymus weights were highest on the third day. Corticosterone and prolactin levels were significantly lower on the fifth andsixth days, respectively. Because SRBC-treated rats showed a peak direct immune response on the fourth and fifth days and showed peak corticosterone levels on the fifth day after treatment, we conclude that the former animals were under stress and influenced their saline conspecifics through sound or smell. This conclusion agrees with other studies, showing that physically or emotionally stressed rats can influence conspecifics through noise andbody odors. (C) 1999 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 05:08:00