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Titolo:
Effect of nitric oxide inhibition on blood pressure and corticosterone responses in adult rats neonatally treated with glutamate
Autore:
Tokarev, D; Jezova, D;
Indirizzi:
Slovak Acad Sci, Inst Expt Endocrinol, SK-83306 Bratislava, Slovakia Slovak Acad Sci Bratislava Slovakia SK-83306 -83306 Bratislava, Slovakia
Titolo Testata:
PHYSIOLOGICAL RESEARCH
, volume: 49, anno: 2000, supplemento:, 1
pagine: S87 - S94
SICI:
0862-8408(2000)49:<S87:EONOIO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOSODIUM GLUTAMATE; NEUROTOXIC LESIONS; HYPERTENSIVE RATS; CHRONIC BLOCKADE; GENE-EXPRESSION; ANGIOTENSIN-II; PLASMA-LEVELS; L-ARGININE; SYNTHASE; ENDOTHELIUM;
Keywords:
monosodium glutamate; nitric oxide; L-NAME; blood pressure; corticosterone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Jezova, D Slovak Acad Sci, Inst Expt Endocrinol, Vlarska 3, SK-83306 Bratislava, Slovakia Slovak Acad Sci Vlarska 3 Bratislava Slovakia SK-83306 Slovakia
Citazione:
D. Tokarev e D. Jezova, "Effect of nitric oxide inhibition on blood pressure and corticosterone responses in adult rats neonatally treated with glutamate", PHYSL RES, 49, 2000, pp. S87-S94

Abstract

The role of nitric oxide (NO) in the regulation of blood pressure and hypothalamic-pituitary-adrenal function of adult rats treated with monosodium glutamate (MSG) during the neonatal period was investigated. Blood pressure and the heart rate were registered by a computerized system of direct bloodpressure measurement through an indwelling cannula in the femoral artery. The inhibition of the activity of NO synthase by acute injection of N-omega-nitro-L-arginine-methylester (L-NAME, 30 mg/kg, i.v.) to control rats produced a rise of blood pressure and a fall of heart rate. Both responses werereduced in MSG-treated rats. Repeated administration of L-NAME (50 mg/kg, i.p, two times daily for 4 days) increased BP in both groups of animals. Corticosterone concentrations in the plasma were significantly increased in response to repeated L-NAME administration in MSG-treated rats, while ACTH levels were similar in both groups of animals. These data suggest that some of the cardiovascular and endocrine changes in rats treated with MSG may bedue to the abnormal function of the NO system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:03:32