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Titolo:
Physiology and genetics of procalcitonin
Autore:
Maruna, P; Nedelnikova, K; Gurlich, R;
Indirizzi:
Charles Univ, Fac Med 1, Internal Dept 3, Prague 12000 2, Czech Republic Charles Univ Prague Czech Republic 12000 2 rague 12000 2, Czech Republic Charles Univ, Fac Med 1, Dept Pathol Physiol, Prague, Czech Republic Charles Univ Prague Czech Republic thol Physiol, Prague, Czech Republic Charles Univ, Fac Med 1, Dept Surg 1, Prague, Czech Republic Charles UnivPrague Czech Republic Dept Surg 1, Prague, Czech Republic
Titolo Testata:
PHYSIOLOGICAL RESEARCH
, volume: 49, anno: 2000, supplemento:, 1
pagine: S57 - S61
SICI:
0862-8408(2000)49:<S57:PAGOP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM PROCALCITONIN; CARDIOPULMONARY BYPASS; SEPSIS; INFECTION;
Keywords:
cytokines; inflammation; procalcitonin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Maruna, P Charles Univ, Fac Med 1, Internal Dept 3, Nemocnice 1, Prague 12000 2, Czech Republic Charles Univ Nemocnice 1 Prague Czech Republic 120002 Republic
Citazione:
P. Maruna et al., "Physiology and genetics of procalcitonin", PHYSL RES, 49, 2000, pp. S57-S61

Abstract

Procalcitonin (PCT), a protein of 116 amino-acids with molecular weight of13 kDa, was discovered 25 years ago as a prohormone of calcitonin producedby C-cells of the thyroid gland and intracellularly cleaved by proteolyticenzymes into the active hormone. Circulating levels of PCT in healthy subjects are below detection limit. Since 1993 when its elevated level was found in patients with bacterial infection, PCT became an important protein in the detection and differential diagnostics of inflammatory states. The production of PCT during inflammation is linked with a bacterial endotoxin and with inflammatory cytokines (TNF, IL-6). PCT delectable in the plasma during inflammation is not produced in C-cells of the thyroid. The probable siteof PCT production during inflammation are the neuroendocrine cells in the lungs or intestine. There is no evidence of plasma PCT binding to cellular receptors of calcitonin, and the role of PCT in calcium and phosphate metabolism during sepsis is still not clear. Other hypothetical roles of PCT (cytokine network regulation, PCT as an endogenous non-steroid antiinflammatory drug) are being considered.

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Documento generato il 04/07/20 alle ore 20:54:15