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Titolo:
Mechanisms of reduced body growth in the pubertal feminized male rat: Unbalanced estrogen and androgen action on the somatotropic axis
Autore:
Pazos, F; Sanchez-Franco, F; Balsa, JA; Escalada, J; Palacios, N; Cacicedo, L;
Indirizzi:
Hosp Ramon y Cajal, Endocrine Serv, E-28034 Madrid, Spain Hosp Ramon y Cajal Madrid Spain E-28034 rine Serv, E-28034 Madrid, Spain Hosp Carlos III, Inst Salud Carlos III, Endocrine Serv, Madrid 28029, Spain Hosp Carlos III Madrid Spain 28029 , Endocrine Serv, Madrid 28029, Spain
Titolo Testata:
PEDIATRIC RESEARCH
fascicolo: 1, volume: 48, anno: 2000,
pagine: 96 - 103
SICI:
0031-3998(200007)48:1<96:MORBGI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RIBONUCLEIC-ACID; RECEPTOR GENE-EXPRESSION; ETHYLENE DIMETHANE SULFONATE; HORMONE-RELEASING FACTOR; FACTOR-I ACTION; GONADAL-STEROIDS; BINDING-PROTEIN; IGF-I; HYPOTHALAMIC SOMATOSTATIN; GH RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Pazos, F Hosp Univ Marques Valdecilla, Endocrine Unit, Avd Valdecilla S-N,Santander 39008, Spain Hosp Univ Marques Valdecilla Avd Valdecilla S-N Santander Spain 39008
Citazione:
F. Pazos et al., "Mechanisms of reduced body growth in the pubertal feminized male rat: Unbalanced estrogen and androgen action on the somatotropic axis", PEDIAT RES, 48(1), 2000, pp. 96-103

Abstract

It is well known that the sex difference in body growth at puberty is modulated by a complex interplay between sex steroids and somatotropic axis; however, the exact role played by sex steroids remains a matter of controversy. The aim of this study was to assess the mechanisms by which sex steroidsregulate body growth during pubertal development. Flutamide, a non-steroid-blocking androgen receptor, was subcutaneously administered to 30-d-old male Wistar rats for 4 wk. The blockade of the androgen receptor led to a marked elevation in serum testosterone and an increment in serum estradiol. Flutamide administration decreased body weight gain, serum IGF-I levels, hepatic IGF-I mRNA, and GH receptor mRNA content. There were no significant changes in serum GH concentration, pituitary GH reserve, and pituitary GH mRNAcontent. Flutamide lowered hypothalamic somatostatin mRNA content and augmented hypothalamic immunoreactive somatostatin stores, but did not alter hypothalamic immunoreactive GH-releasing factor stores. Our findings indicatethat during pubertal development of the male rat, the imbalance between androgen and estrogen actions determines an abnormal somatic growth, which isat least partly exerted through the peripheral or hepatic modification of the somatotropic axis that occurs under the high or exclusive action of estrogens. Potential implication of coincident sex-specific regulated mode of pulsatile GH secretion cannot be excluded from this random serum GPI samplestudy.

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Documento generato il 30/11/20 alle ore 07:05:15