Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dynamic cerebral autoregulation in sick newborn infants
Autore:
Boylan, GB; Young, K; Panerai, RB; Rennie, JM; Evans, DH;
Indirizzi:
Univ London Kings Coll Hosp, Dept Child Hlth, London SE5 9RS, England UnivLondon Kings Coll Hosp London England SE5 9RS ndon SE5 9RS, England Leicester Royal Infirm, Dept Phys Med, Leicester LE1 5WW, Leics, England Leicester Royal Infirm Leicester Leics England LE1 5WW WW, Leics, England
Titolo Testata:
PEDIATRIC RESEARCH
fascicolo: 1, volume: 48, anno: 2000,
pagine: 12 - 17
SICI:
0031-3998(200007)48:1<12:DCAISN>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW VELOCITY; NEONATAL SEIZURES; AUTO-REGULATION; PRETERM INFANTS; PRESSURE; FAILURE; HUMANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Rennie, JM Univ London Kings Coll Hosp, 4th Floor Ruskin Wing,Denmark Hill, London SE6 4DA, England Univ London Kings Coll Hosp 4th Floor Ruskin Wing,Denmark Hill London England SE6 4DA
Citazione:
G.B. Boylan et al., "Dynamic cerebral autoregulation in sick newborn infants", PEDIAT RES, 48(1), 2000, pp. 12-17

Abstract

The sick newborn infant is vulnerable to brain injury and impaired cerebral autoregulation is thought to contribute to this. Coherent averaging is a method of measuring the dynamic cerebral autoregulatory response that is particularly suitable for neonates. We used this method in combination with ameasure of the gradient of the cerebral blood flow velocity (CBFV) response following transient blood pressure (BP) peaks to study dynamic autoregulation in infants undergoing intensive care. Term and preterm infants at highrisk of neurologic injury were compared with a control group of infants, also undergoing intensive care. Simultaneous video-EEG, CBFV (using transcranial Doppler), and arterial blood pressure measurements were obtained intermittently during a study period of at least 2 h. Cerebral autoregulatory response curves were constructed for high risk and control groups. Intact cerebral autoregulation produces a characteristic response consisting of a brief period when CBFV follows arterial blood pressure but quickly returns to baseline value. An impaired autoregulatory response shows CBFV mirroring the arterial blood pressure curve closely. Thirteen high-risk infants, who also had seizures (10 term and 3 preterm) and 12 control infants (6 term and 6 preterm) were studied. Autoregulation was absent in high-risk term and preterm infants. It was also absent in preterm control infants. Term, neurologically healthy infants undergoing intensive care have an intact autoregulatory response. The constant passive response seen in high-risk infants may reflect the severity of the underlying neurologic disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:13:15