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Titolo:
Animal models of schizophrenia
Autore:
De Hert, M; Ellenbroek, B;
Indirizzi:
Univ Ctr St Jozef, B-3070 Kortenberg, Belgium Univ Ctr St Jozef Kortenberg Belgium B-3070 , B-3070 Kortenberg, Belgium Univ Nijmegen, Dept Psychoneuropharmacol, NL-6500 HB Nijmegen, NetherlandsUniv Nijmegen Nijmegen Netherlands NL-6500 HB 0 HB Nijmegen, Netherlands
Titolo Testata:
NEUROSCIENCE RESEARCH COMMUNICATIONS
fascicolo: 3, volume: 26, anno: 2000,
pagine: 279 - 288
SICI:
0893-6609(200005/06)26:3<279:AMOS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDITORY-EVOKED POTENTIALS; PREPULSE INHIBITION; LATENT INHIBITION; STARTLE RESPONSE; RATS; PHENCYCLIDINE; VULNERABILITY; PATHOGENESIS; DOPAMINE;
Keywords:
aetiology; animal models; maternal deprivation; neurodevelopment; review; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: De Hert, M Univ Ctr St Jozef, Leuvensesteenweg 517, B-3070 Kortenberg, Belgium Univ Ctr St Jozef Leuvensesteenweg 517 Kortenberg Belgium B-3070
Citazione:
M. De Hert e B. Ellenbroek, "Animal models of schizophrenia", NEUROSC R C, 26(3), 2000, pp. 279-288

Abstract

Schizophrenia is a complex disorder affecting all domains of human life. Distinction is made between positive (delusions, hallucinations), negative (blunted affect, avolition, social withdrawal), cognitive (attention, executive function, thought disorder) and affective symptoms (anxiety, depression). The vulnerability-stress model is generally used to describe the evolution of the disorder over time and to guide psychosocial and pharmacological treatment. The biological vulnerability to stress is determined by the interaction of genetic and environmental influences. A neuro-developmental model is used to explain the observed structural and functional abnormalities in the brain of schizophrenic patients. In the past most animal models for schizophrenia have been used to developnew medication and to explain the mode of action of antipsychotic drugs. However, in recent years more attention has focused on developing models which may be more related to the schizophrenic (psycho)pathology. The new generation of animal models focus predominantly on mimicking the neurodevelopmental hypothesis of schizophrenia, by manipulating rats in a very early stage of life, and studying the long term consequences. These manipulations include early lesions or maternal deprivation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 09:50:08