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Titolo:
[C-11]Flumazenil binding in the medial temporal lobe in patients with temporal lobe epilepsy - Correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology
Autore:
Lamusuo, S; Pitkanen, A; Jutila, L; Ylinen, A; Partanen, K; Kalviainen, R; Ruottinen, HM; Oikonen, V; Nagren, K; Lehikoinen, P; Vapalahti, M; Vainio, P; Rinne, JO;
Indirizzi:
Univ Turku, Dept Neurol, FIN-20521 Turku, Finland Univ Turku Turku Finland FIN-20521 Dept Neurol, FIN-20521 Turku, Finland Univ Kuopio, Dept Neurosci & Neurol, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 & Neurol, FIN-70211 Kuopio, Finland Univ Kuopio, AI Virtanen Inst, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 nen Inst, FIN-70211 Kuopio, Finland Univ Kuopio, Dept Neurosurg, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 eurosurg, FIN-70211 Kuopio, Finland Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland Kuopio Univ Hosp Kuopio Finland Univ Hosp, Dept Neurol, Kuopio, Finland Kuopio Univ Hosp, Dept Radiol, MRI Unit, Kuopio, Finland Kuopio Univ HospKuopio Finland Dept Radiol, MRI Unit, Kuopio, Finland Turku PET Ctr, PET Unit, Turku, Finland Turku PET Ctr Turku FinlandTurku PET Ctr, PET Unit, Turku, Finland Turku PET Ctr, Radiopharmaceut Chem Lab, Turku, Finland Turku PET Ctr Turku Finland r, Radiopharmaceut Chem Lab, Turku, Finland
Titolo Testata:
NEUROLOGY
fascicolo: 12, volume: 54, anno: 2000,
pagine: 2252 - 2260
SICI:
0028-3878(20000627)54:12<2252:[BITMT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-11 FLUMAZENIL-PET; FIBER SYNAPTIC REORGANIZATION; POSITRON EMISSION TOMOGRAPHY; I-123 IOMAZENIL-SPECT; BENZODIAZEPINE RECEPTORS; ENTORHINAL CORTEX; F-18 FDG; SCLEROSIS; PATHOLOGY; AUTORADIOGRAPHY;
Keywords:
epilepsy; flumazenil; MR volumetry; neuropathology; T2 relaxometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Rinne, JO Univ Turku, Dept Neurol, POB 52, FIN-20521 Turku, Finland Univ Turku POB 52 Turku Finland FIN-20521 -20521 Turku, Finland
Citazione:
S. Lamusuo et al., "[C-11]Flumazenil binding in the medial temporal lobe in patients with temporal lobe epilepsy - Correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology", NEUROLOGY, 54(12), 2000, pp. 2252-2260

Abstract

Objective: To detect reduced [C-11]flumazenil in patients with temporal lobe epilepsy (TLE) and to relate binding to histopathology. Methods: The authors studied 16 patients who underwent epilepsy surgery because of drug-resistant TLE using [C-11]flumazenil PET and quantitative MRI. In 12 patients,resected hippocampus was available for histologic analysis. [C-11]Flumazenil binding potential (fitted BP) was assessed with the simplified referencetissue model. Results: [C-11]Flumazenil fitted BP in the medial temporal lobe was reduced in all patients with abnormal hippocampal volumetry or T2 relaxometry on MRI. Fitted BP was also reduced in 46% of the patients with hippocampal volume within the normal range and in 38% of patients with less than 2 SD T2 prolongation. In all MRI-negative/PET-positive patients, the histologic analysis verified hippocampal damage. Also, [C-11]flumazenil fitted BP correlated with the severity of reduced hippocampal volume, T2 prolongation, and histologically assessed neuronal loss and astrogliosis. Conclusion: [C-11]Flumazenil PET provides a useful tool for investigating the hippocampal damage in vivo even in patients with no remarkable hippocampal abnormalities on quantitative MRI.

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Documento generato il 25/01/20 alle ore 19:32:48