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Titolo:
Vascular abnormalities: the insidious pathogenesis of Alzheimer's disease
Autore:
Shi, J; Perry, G; Smith, MA; Friedland, RP;
Indirizzi:
Case Western Reserve Univ, Inst Pathol, Div Neuropathol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Dept Neurol, Lab Neurogeriatr, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
NEUROBIOLOGY OF AGING
fascicolo: 2, volume: 21, anno: 2000,
pagine: 357 - 361
SICI:
0197-4580(200003/04)21:2<357:VATIPO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL AMYLOID ANGIOPATHY; APOLIPOPROTEIN-E; BETA-PROTEIN; DEMENTIA; APOE; DEPOSITION; RISK; POLYMORPHISMS; VASOACTIVITY; ASSOCIATION;
Keywords:
Alzheimer's disease; cerebrovascular dementia; cardiac vasculature;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Perry, G Case Western Reserve Univ, Inst Pathol, Div Neuropathol, 2085 Adelbert Rd,Cleveland, OH 44106 USA Case Western Reserve Univ 2085 Adelbert RdCleveland OH USA 44106
Citazione:
J. Shi et al., "Vascular abnormalities: the insidious pathogenesis of Alzheimer's disease", NEUROBIOL A, 21(2), 2000, pp. 357-361

Abstract

Alzheimer's disease (AD) and cerebrovascular dementia (CVD) are two major causes of senile dementia in elderly individuals. Mounting evidence from epidemiological, clinical, and neuropathological studies suggests that there is considerable overlap between AD and CVD with respect to risk factors, prevalence, and pathological changes. Although our lack of understanding on the important contribution of vascular disturbance to pathogenesis of AD hasfurther hindered our understanding of AD, data on the roles of cerebrovascular diseases and systemic vascular diseases in AD need to be carefully analyzed to avoid misinterpretation. Here, we review studies on the cerebral vasculature, cardiac vasculature, and apoE that lead us to contend that vascular abnormalities are likely an important mechanism underlying dementia. Because early and aggressive intervention is available to prevent and treat a number of vascular diseases, therapies that attenuate vascular risk factors could be valuable in preventing and treating AD. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:17:26