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Titolo:
Binding of [S-35]GTP gamma S stimulated by (+)-pentazocine, sigma receptoragonist, is abundant in the guinea pig spleen
Autore:
Maruo, J; Yoshida, A; Shimohira, I; Matsuno, K; Mita, S; Ueda, H;
Indirizzi:
Nagasaki Univ, Sch Pharmaceut Sci, Dept Mol Pharmacol & Neurosci, Nagasaki8528521, Japan Nagasaki Univ Nagasaki Japan 8528521 & Neurosci, Nagasaki8528521, Japan Santen Pharmaceut Co Ltd, Cent Res Labs, Osaka 533, Japan Santen Pharmaceut Co Ltd Osaka Japan 533 Cent Res Labs, Osaka 533, Japan
Titolo Testata:
LIFE SCIENCES
fascicolo: 5, volume: 67, anno: 2000,
pagine: 599 - 603
SICI:
0024-3205(20000623)67:5<599:BO[GSS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-S BINDING; NEUROPEPTIDE-Y; SITES; LIGANDS; LOCALIZATION; MEMBRANES; AFFINITY; STATES;
Keywords:
metabotropic sigma receptor; [S-35]GTP gamma S binding; spleen; G protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Ueda, H Nagasaki Univ, Sch Pharmaceut Sci, Dept Mol Pharmacol & Neurosci, 1-14 Bunkyo Machi, Nagasaki 8528521, Japan Nagasaki Univ 1-14 Bunkyo Machi Nagasaki Japan 8528521 521, Japan
Citazione:
J. Maruo et al., "Binding of [S-35]GTP gamma S stimulated by (+)-pentazocine, sigma receptoragonist, is abundant in the guinea pig spleen", LIFE SCI, 67(5), 2000, pp. 599-603

Abstract

Here we measured sigma receptor agonist, [H-3](+)-pentazocine binding and (+)-pentazocine-stimulated [S-35]GTP gamma S binding throughout brain regions and peripheral organs of mice and guinea pigs to investigate the distribution of G protein-coupled sigma receptors. There was no significant correlationship between both distributions, in which the [H-3](+)-pentazocine binding is highest in the liver of each species, while the [S-35]GTP gamma S binding is highest in the guinea pig spleen. The agonist-stimulated [S-35]GTP gamma S binding in the spleen was also confirmed by in situ autoradiography using sections. Thus it is suggested that there are at least two subtypes, metabotropic and nonmetabotropic sigma receptors, and the former ones are abundant in the guinea pig spleen. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 07:05:55