Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Tumour-associated macrophages (TAMS): disordered function, immune suppression and progressive tumour growth
Autore:
Al-Sarireh, B; Eremin, O;
Indirizzi:
Univ Nottingham, Queens Med Ctr, Sect Surg, Nottingham NG7 2UH, England Univ Nottingham Nottingham England NG7 2UH , Nottingham NG7 2UH, England
Titolo Testata:
JOURNAL OF THE ROYAL COLLEGE OF SURGEONS OF EDINBURGH
fascicolo: 1, volume: 45, anno: 2000,
pagine: 1 - 16
SICI:
0035-8835(200002)45:1<1:TM(DFI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; NECROSIS-FACTOR-ALPHA; GUERIN-ACTIVATED MACROPHAGES; NITRIC-OXIDE SYNTHASE; MONOCYTE CHEMOTACTIC PROTEIN-1; MURINE PERITONEAL-MACROPHAGES; DIFFERENT ANATOMICAL SITES; NEOPLASTIC-CELLS INVITRO; CLASS-II MOLECULES; T-CELL;
Keywords:
macrophage; chemotactic factors; promotion of tumour growth; growth factors; anti-tumour activity; cytokines interleukin-1; tumour necrosis factor-alpha; interleukin-10; transforming growth factor-beta; ecosanoids; free radicles; apoptosis; immunosuppression;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
209
Recensione:
Indirizzi per estratti:
Indirizzo: Al-Sarireh, B Univ Nottingham, Queens Med Ctr, Sect Surg, Floor E,West Block, NottinghamNG7 2UH, England Univ Nottingham Floor E,West Block Nottingham England NG7 2UH
Citazione:
B. Al-Sarireh e O. Eremin, "Tumour-associated macrophages (TAMS): disordered function, immune suppression and progressive tumour growth", J ROY COL S, 45(1), 2000, pp. 1-16

Abstract

Evidence currently available suggests that in established, progressively growing solid tumours, tumour associated macrophages (TAMs) are reprogrammedto induce immune suppression of host defenses in situ through release of specific cytokines. prostanoids and other humoral mediators. This disorderedresponse, results in the inhibition of effective anti-cancer cell-mediatedimmune mechanisms. Concurrently, TAM produce tumour growth promoting factors. The summation of this complex interplay of biological factors results in progressive tumour growth and tumour cell dissemination. A better understanding of these complex inter-relationships should form the basis of novel strategies designed to eradicate tumour cells in man and animals. These various biological aspects and processes are discussed in detail and critically evaluated in this review article.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 03:13:38