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Titolo:
Serotonin autoreceptor function and antidepressant drug action
Autore:
Hjorth, S; Bengtsson, HJ; Kullberg, A; Carlzon, D; Peilot, H; Auerbach, SB;
Indirizzi:
Univ Gothenburg, Dept Pharmacol, Inst Physiol & Pharmacol, SE-40530 Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden SE-40530 , SE-40530 Gothenburg, Sweden Rutgers State Univ, Dept Biol Sci, Piscataway, NJ USA Rutgers State Univ Piscataway NJ USA , Dept Biol Sci, Piscataway, NJ USA
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 14, anno: 2000,
pagine: 177 - 185
SICI:
0269-8811(200006)14:2<177:SAFAAD>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO MICRODIALYSIS; POSTSYNAPTIC 5-HT1A RECEPTORS; PLACEBO-CONTROLLED TRIAL; REUPTAKE INHIBITOR CITALOPRAM; DORSAL RAPHE NEURONS; FREELY MOVING RATS; FRONTAL-CORTEX; 5-HYDROXYTRYPTAMINE RELEASE; EXTRACELLULAR SEROTONIN; MAJOR DEPRESSION;
Keywords:
antidepressants; autoreceptors; CNS; 5-HT; 5-HT1A; 5-HT1B; microdialysis, rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
100
Recensione:
Indirizzi per estratti:
Indirizzo: Hjorth, S Univ Gothenburg, Dept Pharmacol, Inst Physiol & Pharmacol, POB 431, SE-40530 Gothenburg, Sweden Univ Gothenburg POB 431 Gothenburg Sweden SE-40530 burg, Sweden
Citazione:
S. Hjorth et al., "Serotonin autoreceptor function and antidepressant drug action", J PSYCHOPH, 14(2), 2000, pp. 177-185

Abstract

This article briefly summarizes, within the context of a brief review of the relevant literature, the outcome of our recent rat microdialysis studieson (1) the relative importance of serotonin (5-HT)(1A) versus 5-HT1B autoreceptors in the mechanism of action of 5-HT reuptake blocking agents, including putative regional differences in this regard, and (2) autoreceptor responsiveness following chronic SSRI administration. First, our data are consistent with the primacy of 5-HT1A autoreceptors in restraining the elevation of 5-HT levels induced by SSRIs, whereas nerve terminal 5-HT1B autoreceptors appear to have an accessory role in this regard. Second, there is an important interplay between cell body and nerve terminal 5-HT autoreceptors, and recent findings suggest that this interplay may potentially be exploited to obtain regionally preferential effects on 5-HT neurotransmission in the central nervous system, even upon systemic drug administration. In particular, emerging data suggest that somatodendritic 5-HT1A autoreceptor- and nerve terminal 5-HT1B autoreceptor-mediated feedback may be relatively more important in the control of 5-HT output in dorsal raphe-frontal cortex and median raphe-dorsal hippocampus systems, respectively. Third, 5-HT autoreceptors evidently retain the capability to limit the 5-HT transmission-promoting effect of SSRIs after chronic treatment. Thus, although the responsiveness of these sites is probably somewhat reduced, residual autoreceptor capacity still remains an effective restraint on large increases in extracellular 5-HT, even after prolonged treatment. If a further increase in extracellular 5-HT is crucial to the remission of depression in patients responding only partially to prolonged administration of antidepressants, then sustained adjunctive treatment with autoreceptor-blocking drugs may consequently prove useful in the long term.

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Documento generato il 05/04/20 alle ore 04:55:53