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Titolo:
Behavioural effects of acute tryptophan depletion in healthy male volunteers
Autore:
Shansis, FM; Busnello, JV; Quevedo, J; Forster, L; Young, S; Izquierdo, I; Kapczinski, F;
Indirizzi:
Hosp Clin Porto Alegre, Serv Psiquiat, Grp Psicofarmacol, BR-9003503 PortoAlegre, RS, Brazil Hosp Clin Porto Alegre Porto Alegre RS Brazil BR-9003503 egre, RS, Brazil Univ Fed Rio Grande Sul, Fac Med, Dept Psiquiat, Grp Psicofarmacol, Porto Alegre, RS, Brazil Univ Fed Rio Grande Sul Porto Alegre RS Brazil Porto Alegre, RS, Brazil Univ Fed Rio Grande Sul, Inst Ciencias Basicas Saude, Dept Bioquim, Ctr Memoria, Porto Alegre, RS, Brazil Univ Fed Rio Grande Sul Porto Alegre RS Brazil Porto Alegre, RS, Brazil McGill Univ, Dept Psychiat, Montreal, PQ H3A 2T5, Canada McGill Univ Montreal PQ Canada H3A 2T5 hiat, Montreal, PQ H3A 2T5, Canada
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 14, anno: 2000,
pagine: 157 - 163
SICI:
0269-8811(200006)14:2<157:BEOATD>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAPID DEPLETION; PLASMA TRYPTOPHAN; MOOD; PERFORMANCE; ANXIETY; MEMORY;
Keywords:
acute tryptophan depletion; anxiety; attention; memory; mood; serotonin; simulated public speaking;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Kapczinski, F Hosp Clin Porto Alegre, Serv Psiquiat, Grp Psicofarmacol, Rua Ramiro Barcelos 2350, BR-9003503 Porto Alegre, RS, Brazil Hosp Clin PortoAlegre Rua Ramiro Barcelos 2350 Porto Alegre RS Brazil BR-9003503
Citazione:
F.M. Shansis et al., "Behavioural effects of acute tryptophan depletion in healthy male volunteers", J PSYCHOPH, 14(2), 2000, pp. 157-163

Abstract

Acute tryptophan depletion (ATD) studies have been used to assess the roleof the serotonergic system in various aspects of human behaviour. Changes in mood have already been described in selected groups of individuals submitted to ATD. The present study was a randomized, double-blind, cross-over trial designed to evaluate the effects of ATD on mood, memory, attention andinduced anxiety in normal male volunteers. Twelve healthy male volunteers were submitted to two separate sessions of ATD, 1 week apart. Drinks containing either a balanced mixture of amino acids (B) or a similar mixture devoid of tryptophan (T-) were administered in each session. Mood was assessed using self-rating scales, Attention and memory were assessed using a battery of psychological tests. Anxiety induction was carried out using a simulation of public speaking. Blood levels of tryptophan were assessed before andafter the B and T- drinks. Results showed that ATD markedly decreased plasma tryptophan (p < 0.0001). Mood ratings, memory and attention were not changed by the T- drink. There was no difference among the anxiety levels measured under T- or B mixtures. These data supports the notion that ATD does not change mood and cognitive function in healthy subjects.

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Documento generato il 03/04/20 alle ore 20:31:07