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Titolo:
Adrenal glucocorticoids modulate [H-3]cyclic AMP binding to protein kinasea (PKA), cyclic AMP-cependent PKA activity, and protein levels of selective regulatory and catalytic subunit isoforms of PKA in rat brain
Autore:
Dwivedi, Y; Pandey, GN;
Indirizzi:
Univ Illinois, Coll Med, Inst Psychiat, Dept Psychiat, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 , Dept Psychiat, Chicago, IL 60612 USA
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 1, volume: 294, anno: 2000,
pagine: 103 - 116
SICI:
0022-3565(200007)294:1<103:AGM[AB>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-ADRENERGIC RECEPTORS; MAJOR DEPRESSION; PHOSPHOLIPASE-C; MESSENGER-RNA; DEXAMETHASONE; EXPRESSION; BEHAVIOR; GS; CORTICOSTEROIDS; FIBROBLASTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Dwivedi, Y Univ Illinois, Coll Med, Inst Psychiat, Dept Psychiat, M-C 912,1601 W Taylor St, Chicago, IL 60612 USA Univ Illinois M-C 912,1601 W TaylorSt Chicago IL USA 60612 USA
Citazione:
Y. Dwivedi e G.N. Pandey, "Adrenal glucocorticoids modulate [H-3]cyclic AMP binding to protein kinasea (PKA), cyclic AMP-cependent PKA activity, and protein levels of selective regulatory and catalytic subunit isoforms of PKA in rat brain", J PHARM EXP, 294(1), 2000, pp. 103-116

Abstract

Alterations in hypothalamic-pituitary-adrenal (HPA) function are associated with changes in mood and behavior. Protein kinase A (PKA), on activation,phosphorylates many important intracellular proteins and thereby plays a major role in mediating various physiological functions in brain. We systematically examined the relationship of altered HPA function with PKA modifications in rat brain after administering corticosterone to normal rats and byfirst adrenalectomizing rats and then simultaneously treating them with different doses of corticosterone. Rats were decapitated on day 1, 4, or 14. Subcutaneously implanted 50- or 100-mg corticosterone pellets in normal rats for 4 or 14 days significantly decreased PKA activity, B-max of [H-3]cyclic AMP binding, and protein levels of selective PKA regulatory (RI alpha, RII beta) and catalytic (Cat beta) subunit isoforms in cortex and hippocampus in a dose-dependent manner without any significant changes at day 1; these changes were more pronounced at day 14. However, adrenalectomy caused theopposite changes in these measures at day 4 or 14 in both cortex and hippocampus, and the magnitude of the changes was more pronounced at day 14. Simultaneous treatment with implanted corticosterone at 50- or 100-mg doses inadrenalectomized rats reversed the adrenalectomy-induced increases in PKA measures in a dose-dependent manner. These results suggest that endogenous glucocorticoid modifies the expression of RI alpha, RII alpha, and Cat betasubunit isoforms of PKA, as well as the catalytic and regulatory activities of PKA, and that these alterations in PKA may in part explain HPA axis-mediated changes in mood and behavior.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 02:07:48