Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Chronic oral administration of ATP modulates nucleoside transport and purine metabolism in rats
Autore:
Kichenin, K; Seman, M;
Indirizzi:
Univ Paris 07, Grp Immunol Denis Diderot, F-75251 Paris 05, France Univ Paris 07 Paris France 05 ol Denis Diderot, F-75251 Paris 05, France
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 1, volume: 294, anno: 2000,
pagine: 126 - 133
SICI:
0022-3565(200007)294:1<126:COAOAM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTIONAL EXPRESSION; MOLECULAR-CLONING; ADENINE-NUCLEOTIDES; MAMMALIAN-CELLS; SMALL-INTESTINE; ADENOSINE; NITROBENZYLTHIOINOSINE; EI; COTRANSPORTER; LOCALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Kichenin, K Univ Paris 07, Grp Immunol Denis Diderot, Hall Biotechnol,Tour54,CP7124,2Pl Jussieu, F-75251 Paris 05, France Univ Paris 07 Hall Biotechnol,Tour 54,CP7124,2 Pl Jussieu Paris France 05
Citazione:
K. Kichenin e M. Seman, "Chronic oral administration of ATP modulates nucleoside transport and purine metabolism in rats", J PHARM EXP, 294(1), 2000, pp. 126-133

Abstract

The effect of repeated oral administration of ATP on purine transport and metabolism was investigated in rats. An increased ability of the gut to capture intraluminal purine nucleosides and to export ATP and nucleosides toward portal bloodstream was observed in rats after 30 days of treatment with 5 mg/kg/day ATP. This was accompanied in erythrocytes by an increased transport of adenosine rapidly transformed into ATP, which in turn was exported toward extracellular fluid. However, these metabolic changes were associated with a paradoxical and progressive diminution of plasma ATP level below that found in control rats and that was not strictly dependent on the ATP dose administered, whereas plasma adenosine concentration remained unchanged. This diminution likely resulted from an increased ectonucleotidase activity, suggesting that the chronic administration of ATP seems to induce a progressive adaptation of purine metabolism. This adaptive response to free purine supplementation affects both intracellular metabolism and purine exchange between intracellular and extracellular compartments. This modification of free purine turnover and delivery may affect physiological parameters under the control of P-1 and P-2 purinoceptors described in different experimental models.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:27:31