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Titolo:
Validation of a LC method for the analysis of zafirlukast in a pharmaceutical formulation
Autore:
Ficarra, R; Ficarra, P; Tommasini, S; Melardi, S; Calabro, ML; Furlanetto, S; Semreen, M;
Indirizzi:
Univ Messina, Dipartimento Farmacochim, I-98168 Messina, Italy Univ Messina Messina Italy I-98168 o Farmacochim, I-98168 Messina, Italy Univ Magna Graecia, Fac Farm, Catanzaro, Italy Univ Magna Graecia Catanzaro Italy Graecia, Fac Farm, Catanzaro, Italy Univ Florence, Dipartimento Sci Farmaceut, I-50121 Florence, Italy Univ Florence Florence Italy I-50121 Farmaceut, I-50121 Florence, Italy
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 1, volume: 23, anno: 2000,
pagine: 169 - 174
SICI:
0731-7085(20000801)23:1<169:VOALMF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
KYNURENIC ACID DETERMINATION; HUMAN PLASMA; URINE;
Keywords:
zafirlukast; reversed phase high performance liquid chromatography; validation; intermediate precision; robustness testing; experimental design;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Ficarra, P Univ Messina, Dipartimento Farmacochim, Viale Annunziata, I-98168 Messina,Italy Univ Messina Viale Annunziata Messina Italy I-98168 sina,Italy
Citazione:
R. Ficarra et al., "Validation of a LC method for the analysis of zafirlukast in a pharmaceutical formulation", J PHARM B, 23(1), 2000, pp. 169-174

Abstract

A reversed-phase high-performance liquid chromatographic (HPLC) method wasdeveloped and validated for estimation of zafirlukast in a pharmaceutical formulation. Assay samples were extracted utilizing acetonitrile. Drug and internal standard were chromatographed on reversed-phase C-18 columns, using mixtures of acetonitrile/water and the eluents were monitored at different wavelengths. The method was validated statistically for its linearity, accuracy, robustness and precision. Experimental design was used during validation to evaluate method robustness and for the determination of intermediate precision. Factors examined for statistical approaches include laboratory, day, analyst, instrument, different percentage of organic modifier, temperature, wavelength and flow-rate. Due to its simplicity and accuracy, the method may be used for routine quality control analysis. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 14:03:53