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Titolo:
Activated platelets induce secretion of interleukin-1 beta, monocyte chemotactic protein-1, and macrophage inflammatory protein-1 alpha and surface expression of intercellular adhesion molecule-1 on cultured endothelial cells
Autore:
Cha, JK; Jeong, MH; Bae, HR; Han, JY; Jeong, SJ; Jin, HJ; Lim, YJ; Kim, SH; Kim, JW;
Indirizzi:
Dong A Univ, Sch Med, Inst Med Sci, Pusan, South Korea Dong A Univ PusanSouth Korea Sch Med, Inst Med Sci, Pusan, South Korea Dong A Univ, Sch Med, Dept Neurol, Pusan, South Korea Dong A Univ Pusan South Korea Sch Med, Dept Neurol, Pusan, South Korea
Titolo Testata:
JOURNAL OF KOREAN MEDICAL SCIENCE
fascicolo: 3, volume: 15, anno: 2000,
pagine: 273 - 278
SICI:
1011-8934(200006)15:3<273:APISOI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
KAPPA-B; MECHANISMS; ATHEROSCLEROSIS; RECRUITMENT; PLAQUE;
Keywords:
blood platelets; endothelium; cell adhesion molecules; atherosclerosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Cha, JK Dong A Univ Hosp, Sch Med, Dept Neurol, 1,3-Ga Dongdaesin Dong, Pusan 602705, South Korea Dong A Univ Hosp 1,3-Ga Dongdaesin Dong Pusan South Korea 602705
Citazione:
J.K. Cha et al., "Activated platelets induce secretion of interleukin-1 beta, monocyte chemotactic protein-1, and macrophage inflammatory protein-1 alpha and surface expression of intercellular adhesion molecule-1 on cultured endothelial cells", J KOR MED S, 15(3), 2000, pp. 273-278

Abstract

Atherosclerosis is an inflammatory disease. Platelet-endothelium interaction plays an important role in the pathophysiology of atherogenesis. We investigated the role of activated platelets for secretion of interleukin (IL)-1 beta, monocyte chemotactic protein (MCP)-1 and macrophage inflammatory protein (MIP)-1 alpha and expression of intercellular adhesion molecule (ICAM)-1 on endothelial cells. Human umbilical vein endothelial cells (HUVEC) were incubated with nonstimulated or ADP-activated platelets for 6 hr. Secretion of interleukin (IL)-1 beta, MCP-1 and MIP-1 alpha and surface expression of ICAM-1 were measured by ELISA and flow cytometry. In the presence of activated platelets, the secretion of IL-1 beta, MCP-1, and MIP-1 alpha and surface expression of ICAM-1 were significantly increased compared with non-activated platelets. The present study shows that activated platelets may contribute to expression of various inflammatory mediators on endothelial cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 10:45:11