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Titolo:
Cetirizine and loratadine: a comparison using the ED50 in skin reactions
Autore:
Ramboer, I; Bumbacea, R; Lazarescu, D; Radu, JR;
Indirizzi:
UCB SA, Pharma Sector, B-1420 Braine Alleud, Belgium UCB SA Braine Alleud Belgium B-1420 ector, B-1420 Braine Alleud, Belgium Malaxa Hosp, Bucharest, Romania Malaxa Hosp Bucharest RomaniaMalaxa Hosp, Bucharest, Romania
Titolo Testata:
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
fascicolo: 2, volume: 28, anno: 2000,
pagine: 69 - 77
SICI:
0300-0605(200003/04)28:2<69:CALACU>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLARE REACTIONS; INDUCED WHEAL; DOUBLE-BLIND; HISTAMINE; TERFENADINE; SUPPRESSION; MODULATION; ASTEMIZOLE; ANTIGEN; PLACEBO;
Keywords:
cetirizine; loratadine; antihistamines; skin reactions; histamine prick test; ED50;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Ramboer, I UCB SA, Pharma Sector, Chemin Foriest, B-1420 Braine Alleud, Belgium UCB SA Chemin Foriest Braine Alleud Belgium B-1420 ud, Belgium
Citazione:
I. Ramboer et al., "Cetirizine and loratadine: a comparison using the ED50 in skin reactions", J INT MED R, 28(2), 2000, pp. 69-77

Abstract

To quantify objectively the comparative potencies of the antihistamines, loratadine and cetirizine, we determined the dose that inhibits histamine-induced skin reactions by 50% of the maximum response (ED50) for each drug. Cetirizine at 2.5, 5 or 10 mg, loratadine at 10, 20 or 40 mg or placebo weregiven to 14 healthy female subjects in a randomized double-blind crossoverdesign. Inhibition of the wheal and flare response to the histamine prick test (10, 100 and 500 mg/ml) was evaluated. Depending on the histamine concentrations, the ED50 for wheals were in the ranges 4.3 - 4.7, 2.1 - 2.2 and1.7 - 1.9 mg cetirizine, 2, 4 and 6 h after dosing, respectively. For loratadine, the ED50 for wheals were in the ranges 35.6 - > 40, 9.1 - 24.1 and 9.1 - 13.9 mg, 2, 4 and 6 h after dosing, respectively. Calculation of the ED50 demonstrated that, on average, cetirizine is seven to nine times more potent than loratadine at inhibiting wheal and flare reactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/18 alle ore 08:13:07