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Titolo:
Structural study of the interaction of vanadate with the ligand 1,2-dimethyl-3-hydroxy-4-pyridinone (Hdmpp) in aqueous solution
Autore:
Castro, MMCA; Geraldes, CFGC; Gameiro, P; Pereira, E; Castro, B; Rangel, M;
Indirizzi:
Univ Coimbra, Fac Ciencias & Tecnol, Dept Bioquim, P-3000 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3000 t Bioquim, P-3000 Coimbra, Portugal Univ Coimbra, Ctr Neurociencias, P-3000 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3000 ociencias, P-3000 Coimbra, Portugal Univ Porto, Fac Ciencias, CEQUP, Dept Quim, P-4169007 Porto, Portugal UnivPorto Porto Portugal P-4169007 Dept Quim, P-4169007 Porto, Portugal Univ Porto, CEQUP, Inst Ciencias Biomed Abel Salazar, P-4099003 Porto, Portugal Univ Porto Porto Portugal P-4099003 l Salazar, P-4099003 Porto, Portugal
Titolo Testata:
JOURNAL OF INORGANIC BIOCHEMISTRY
fascicolo: 1-2, volume: 80, anno: 2000,
pagine: 177 - 179
SICI:
0162-0134(20000530)80:1-2<177:SSOTIO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIABETIC RATS;
Keywords:
vanadate; 1,2-dimethyl-3-hydroxy-4-pyridinone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Castro, MMCA Univ Coimbra, Fac Ciencias & Tecnol, Dept Bioquim, P-3000 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3000 3000 Coimbra, Portugal
Citazione:
M.M.C.A. Castro et al., "Structural study of the interaction of vanadate with the ligand 1,2-dimethyl-3-hydroxy-4-pyridinone (Hdmpp) in aqueous solution", J INORG BIO, 80(1-2), 2000, pp. 177-179

Abstract

The interaction of vanadate with the ligand 1,2-dimethyl-3-hydroxy-4-pyridinone (Hdmpp) was studied in aqueous solution using a combination of multinuclear NMR and EPR spectroscopies, as well as potentiometry and cyclic voltammetry. The different species in solution were identified and characterized, and their pK(a) values and stability constants determined. The vanadium complexes formed in solution are strongly dependent on media composition (ionic strength, presence of buffer), pH and metal-to-ligand ratio (M:L). Twomajor species - V(V)/dmpp and V(V)/(dmpp)(2) - are formed in a 140 mM NaClsolution within the pH range 4.5 to 9.0, when M:L = 1:2. In the presence of excess ligand (M:L less than or equal to 1:5), only the 1:2 complex is present, and at pH < 4 paramagnetic species are detected by EPR in solution, thus indicating a reducing capacity of the ligand. Cyclic voltammetry showsthat redox processes in solution are not just electron transfer, but are accompanied by chemical reactions. The pK(a) values and stability constants were determined both by V-51 NMR spectroscopy and potentiometry. The present results have a particular interest in the understanding of the aqueous solution chemistry in aerobic conditions of bis(1,2-dimethyl-3-hydroxy-4-pyridinonato) oxovanadium(IV) complex, VO(dmpp)(2), a vanadium compound with potential insulin-mimetic properties. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:08:59