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Titolo:
Early alterations of myocardial blood flow reserve in heart transplant recipients with angiographically normal coronary arteries
Autore:
Preumont, N; Berkenboom, G; Vachiery, JL; Jansens, JL; Antoine, M; Wikler, D; Damhaut, P; Degre, S; Lenaers, A; Goldman, S;
Indirizzi:
Free Univ Brussels, Erasme Hosp, Dept Cardiol, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 iol, B-1070 Brussels, Belgium Free Univ Brussels, Erasme Hosp, Dept Cardiac Surg, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 urg, B-1070 Brussels, Belgium Free Univ Brussels, Erasme Hosp, PET Biomed Cyclotron Unit, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 nit, B-1070 Brussels, Belgium
Titolo Testata:
JOURNAL OF HEART AND LUNG TRANSPLANTATION
fascicolo: 6, volume: 19, anno: 2000,
pagine: 538 - 545
SICI:
1053-2498(200006)19:6<538:EAOMBF>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CARDIAC TRANSPLANTATION; N-13 AMMONIA; NONINVASIVE QUANTIFICATION; VASODILATION; EXERCISE; PERFUSION; REJECTION; DISEASE; HUMANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Preumont, N Free Univ Brussels, Erasme Hosp, Dept Cardiol, Route Lennik 808, B-1070 Brussels, Belgium Free Univ Brussels Route Lennik 808 Brussels Belgium B-1070 m
Citazione:
N. Preumont et al., "Early alterations of myocardial blood flow reserve in heart transplant recipients with angiographically normal coronary arteries", J HEART LUN, 19(6), 2000, pp. 538-545

Abstract

Background: The evaluation of the coronary reserve provides valuable information on the status of coronary vessels. Therefore, we studied with positron emission tomography (PET) and 13N-ammonia the myocardial blood flow (MBF) reserve in heart transplant: recipients free of allograft rejection and with angiographically normal coronary arteries early after heart transplantation (HTx). The MBF reserve was calculated as the ratio between MBF after dipyridamole injection and basal MBF normalized for the rate-pressure product. Methods: Patients were studied within 3 months (group A, n = 12) or more than 9 months (group B, n = 12) after HTx. Five patients have been studied both during the early and late period after HTx. Results were compared to those obtained in 7 normal volunteers (NL). Results: Group A recipients had a significantly lower dipyridamole MBF (inml/min/100 gr of tissue) than that of group B recipients (142 +/- 34 vs 195 +/- 59, p < 0.05). This resulted in a significant decrease in MBF reserveearly after HTx (group A: 1.82 +/- 0.33) and a restoration to normal values thereafter (group B: 2.52 +/- 0.53 vs NL: 2.62 +/- 0.51,p = ns). Separateanalysis of 5 patients studied twice is consistent with these results. Conclusion: This study shows that in heart transplant recipients free of allograft rejection and with normal coronary angiography, MBF reserve is impaired early after HTx. Restoration within one year suggests that this abnormality does not represent an early stage of cardiac allograft vasculopathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:29:03