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Titolo:
Comparison of alternative designs for reducing complex neurons to equivalent cables
Autore:
Burke, RE;
Indirizzi:
NINDS, Neural Control Lab, NIH, Bethesda, MD 20895 USA NINDS Bethesda MD USA 20895 ural Control Lab, NIH, Bethesda, MD 20895 USA
Titolo Testata:
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
fascicolo: 1, volume: 9, anno: 2000,
pagine: 31 - 47
SICI:
0929-5313(200007)9:1<31:COADFR>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDENTIFIED ALPHA-MOTONEURONS; CAT SPINAL-CORD; SOMATIC SHUNT; ELECTROTONIC ARCHITECTURE; DENDRITIC STRUCTURE; MEMBRANE-PROPERTIES; TRANSIENT-RESPONSE; GAMMA-MOTONEURONS; ONE BRANCH; MODEL;
Keywords:
electrotonic models; voltage transients; attenuation; voltage propagation delay;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Burke, RE NINDS, Neural Control Lab, NIH, Bethesda, MD 20895 USA NINDS Bethesda MD USA 20895 ol Lab, NIH, Bethesda, MD 20895 USA
Citazione:
R.E. Burke, "Comparison of alternative designs for reducing complex neurons to equivalent cables", J COMPUT N, 9(1), 2000, pp. 31-47

Abstract

Reduction of the morphological complexity of actual neurons into accurate,computationally efficient surrogate models is an important problem in computational neuroscience. The present work explores the use of two morphoelectrotonic transformations, somatofugal voltage attenuation (AT cables) and signal propagation delay (DL cables), as bases for construction of electrotonically equivalent cable models of neurons. In theory, the AT and DL cablesshould provide more accurate lumping of membrane regions that have the same transmembrane potential than the familiar equivalent cables that are based only on somatofugal electrotonic distance (LM cables). In practice, AT and DL cables indeed provided more accurate simulations of the somatic transient responses produced by fully branched neuron models than LM cables. Thiswas the case in the presence of a somatic shunt as well as when membrane resistivity was uniform.

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Documento generato il 28/09/20 alle ore 17:27:13