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Titolo:
Sympathectomy, which induces membranous bone remodeling, has no effect on endochondral long bone remodeling in vivo
Autore:
Sherman, BE; Chole, RA;
Indirizzi:
Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 & Neck Surg, St Louis, MO 63110 USA Univ Calif Davis, Sch Med, Dept Otolaryngol Head & Neck Surg, Sacramento, CA 95817 USA Univ Calif Davis Sacramento CA USA 95817 k Surg, Sacramento, CA 95817 USA
Titolo Testata:
JOURNAL OF BONE AND MINERAL RESEARCH
fascicolo: 7, volume: 15, anno: 2000,
pagine: 1354 - 1360
SICI:
0884-0431(200007)15:7<1354:SWIMBR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUANETHIDINE-INDUCED SYMPATHECTOMY; INTRAMEMBRANOUS BONE; INDUCED DESTRUCTION; RESORPTION; RATS; MECHANISM; NEURONS;
Keywords:
endochondral long bone; membranous bone; remodeling; sympathectomy; guanethidine sulfate; 6-hydroxydopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Chole, RA Washington Univ, Sch Med, Dept Otolaryngol, 517 S Euclid Ave,Campus Box 8115, St Louis, MO 63110 USA Washington Univ 517 S Euclid Ave,Campus Box 8115 St Louis MO USA 63110
Citazione:
B.E. Sherman e R.A. Chole, "Sympathectomy, which induces membranous bone remodeling, has no effect on endochondral long bone remodeling in vivo", J BONE MIN, 15(7), 2000, pp. 1354-1360

Abstract

Sympathectomy has been shown to induce resorption within the membranous middle ear bone of gerbils, It is unknown whether sympathectomy exerts a similar effect on endochondral long bone. In the present study, guanethidine sulfate (GS) and 6-hydroxydopamine (HDA) were administered to gerbils to induce sympathectomy, One week later, samples of middle ear bulla bone and radial long bone were harvested and assessed for osteoclastic activity. Histomorphometric analysis showed both pharmacologic sympathectomy with GS and chemical sympathectomy with HDA significantly increased the osteoclast counts and osteoclast surfaces of bulla bone samples but not radial long bone samples, respectively. In contrast, RDA but not GS increased the osteoclast profile area of both long bone and membranous bone samples when compared with vehicle-treated controls. Sympathectomy, induced both chemically and pharmacologically, thus has been shown to increase resorption in membranous bone but not endochondral long bone in the gerbilline model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 09:54:31