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Titolo:
Genetic determination of Colles' fracture and differential bone mass in women with and without Colles' fracture
Autore:
Deng, HW; Chen, WM; Recker, S; Stegman, MR; Li, JL; Davies, KM; Zhou, Y; Deng, HY; Heaney, R; Recker, RR;
Indirizzi:
Creighton Univ, Osteoporosis Res Ctr, Omaha, NE 68131 USA Creighton Univ Omaha NE USA 68131 teoporosis Res Ctr, Omaha, NE 68131 USA Creighton Univ, Dept Biomed Sci, Omaha, NE 68178 USA Creighton Univ OmahaNE USA 68178 v, Dept Biomed Sci, Omaha, NE 68178 USA
Titolo Testata:
JOURNAL OF BONE AND MINERAL RESEARCH
fascicolo: 7, volume: 15, anno: 2000,
pagine: 1243 - 1252
SICI:
0884-0431(200007)15:7<1243:GDOCFA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
VITAMIN-D-RECEPTOR; QUANTITATIVE-TRAIT LOCI; NATIONAL-OSTEOPOROSIS-FOUNDATION; DISCORDANT SIB PAIRS; MINERAL DENSITY; HIP FRACTURE; POSTMENOPAUSAL WOMEN; UNITED-STATES; RISK-FACTORS; OLDER WOMEN;
Keywords:
Colles' fracture; heritability; osteoporotic fracture; genetic determination; relative risk; recurrence risk;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Recker, RR Creighton Univ, Osteoporosis Res Ctr, 601 N 30th St, Omaha, NE 68131 USA Creighton Univ 601 N 30th St Omaha NE USA 68131 a, NE 68131 USA
Citazione:
H.W. Deng et al., "Genetic determination of Colles' fracture and differential bone mass in women with and without Colles' fracture", J BONE MIN, 15(7), 2000, pp. 1243-1252

Abstract

Osteoporotic fractures (OFs) are a major public health problem. Direct evidence of the importance and, particularly, the magnitude of genetic determination of OF per se is essentially nonexistent. Colles' fractures (CFs) area common type of OF. In a metropolitan white female population in the midwestern United States, we found significant genetic determination of CP. Theprevalence (K) of CF is, respectively, 11.8% (+/-SE 0.7%) in 2471 proband women aged 65.55 years (0.21), 4.4% (0.3%) in 3803 sisters of the probands,and 14.6% (0.7%) in their mothers. The recurrence risk (K-0), the probability that a woman will suffer CF if her mother has suffered CF is 0.155 (0.017). The recurrence risk (K-s), the probability that a sister of a proband woman will suffer CF given that her proband sister has suffered CF is 0.084(0.012). The relative risk lambda (the ratio of the recurrence risk to K),which measures the degree of genetic determination of complex diseases such as CF, is 1.312 (0.145; lambda(0)) for a woman with an affected mother and 1.885 (0.276; lambda(s)) for a woman with an affected sister. A lambda-value significantly greater than 1.0 indicates genetic determination of CF. The terms lambda(0) and lambda(s) are related to the genetic variances of CF. These parameters translate into a significant and moderately high heritability (0.254 [0.118]) for CF. These parameters were estimated by a maximum likelihood method that we developed, which provides a general tool for characterizing genetic determination of complex diseases. In addition, we foundthat women without CF had significantly higher bone mass (adjusted for important covariates such as age, weight, etc.) than women with CF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 17:57:26