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Titolo:
Serum triglycerides, HIV infection, and highly active antiretroviral therapy, Aquitaine Cohort, France, 1996 to 1998
Autore:
Thiebaut, R; Dabis, F; Malvy, F; Jacqmin-Gadda, H; Mercie, P; Valentin, VD;
Indirizzi:
Univ Bordeaux 2, Unite INSERM 330, F-33076 Bordeaux, France Univ Bordeaux 2 Bordeaux France F-33076 RM 330, F-33076 Bordeaux, France Ctr Hosp Univ, Ctr Informat & Soins Immunodeficience Humaine, Bordeaux, France Ctr Hosp Univ Bordeaux France mmunodeficience Humaine, Bordeaux, France
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 3, volume: 23, anno: 2000,
pagine: 261 - 265
SICI:
1525-4135(20000301)23:3<261:STHIAH>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; PROTEASE INHIBITORS; METABOLIC ABNORMALITIES; INSULIN-RESISTANCE; BODY-FAT; RITONAVIR; HYPERLIPIDEMIA; LIPODYSTROPHY; LIPIDS; HYPERTRIGLYCERIDEMIA;
Keywords:
triglycerides; HIV infection; protease inhibitors; longitudinal studies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Dabis, F Univ Bordeaux 2, Unite INSERM 330, 146 Rue Leo Saignat, F-33076 Bordeaux, France Univ Bordeaux 2 146 Rue Leo Saignat Bordeaux France F-33076 ance
Citazione:
R. Thiebaut et al., "Serum triglycerides, HIV infection, and highly active antiretroviral therapy, Aquitaine Cohort, France, 1996 to 1998", J ACQ IMM D, 23(3), 2000, pp. 261-265

Abstract

The aim of this study was to identify factors associated with serum triglyceride (TG) evolution in HIV-1-infected patients when highly active antiretroviral treatment (HAART) with or without protease inhibitors (PI) was introduced. Among 3191 patients of the Aquitaine Cohort (multirisk, both genders, multiple treatment patterns) observed during 1996 through 1998, 1429 hadat least two measurements of TG, vital load, and CD4 cell count. Median follow-up was 21 months (interquartile range [IQR], 11-26) and median number of TG measures was 6 (IQR, 3-10). Median TG at baseline was 1.32 mmoy/L (IQR, 0.91-2.05) and increased significantly over time (+2.5% for 100 days; 95% confidence interval [CI], 1.9-3.1). Longitudinal analysis of variations of TG was performed using mixed models. In crude analysis, baseline TG was higher in men, in those aged over 36 years, and in homosexuals. The following time-dependent variables were associated with an increase of TG: body weight increasing to >65 kg, diagnosis of AIDS, CD4 cell count falling to <50 cells/mm(3), viral load falling to <500 cp/ml, and introduction of nucleoside analogues and PIs. In multivariate analysis, age >36 years (change of +17% of the TG level; 95% CT, 11-24), homosexuals (+13%; 95% CI, 4-23), AIDS stage (+12%; 95% CI, 5-19), weight >65 kg (+7%; 95% CI, 2-12) and PI (+21%;95% CI, 17-27) remained significant. Factors identified before the availability of PI remain important but HAART with PI is a new major contributing factor to increased TG levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:53:41