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Titolo:
Dual nucleoside regimens in nonadvanced HIV infection: Prospective follow-up of 130 patients, Aquitaine Cohort, 1996 to 1998
Autore:
Morlat, P; Marimoutou, C; Dequae-Merchadou, L; Pellegrin, I; Mercie, I; Neau, D; Beylot, J; Dabis, F;
Indirizzi:
CHU Bordeaux, Serv Med Interne & Malad Infect, Hop St Andre, F-33075 Bordeaux, France CHU Bordeaux Bordeaux France F-33075 St Andre, F-33075 Bordeaux, France Univ Victor Segalen Bordeaux 2, INSERM U330, Bordeaux, France Univ Victor Segalen Bordeaux 2 Bordeaux France M U330, Bordeaux, France CHU, Ctr Informat & Soins Immunodeficience Humaine, CISIH, Bordeaux, France CHU Bordeaux France s Immunodeficience Humaine, CISIH, Bordeaux, France CHU, Hop Pellegrin, Virol Lab, Bordeaux, France CHU Bordeaux FranceCHU, Hop Pellegrin, Virol Lab, Bordeaux, France CHU Bordeaux, Hop Haut Leveque, Serv Med Interne & Malad Infect, Pessac, France CHU Bordeaux Pessac France v Med Interne & Malad Infect, Pessac, France CHU, Hop Pellegrin, Dept Malad Infect, Bordeaux, France CHU Bordeaux France Hop Pellegrin, Dept Malad Infect, Bordeaux, France
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 3, volume: 23, anno: 2000,
pagine: 255 - 260
SICI:
1525-4135(20000301)23:3<255:DNRINH>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVE ANTIRETROVIRAL THERAPY; PLASMA VIRAL LOAD; PROTEASE INHIBITORS; DISEASE; COMBINATIONS; PROGRESSION; DIDANOSINE; ZIDOVUDINE; COPIES/ML; FAILURE;
Keywords:
dual nucleoside reverse transcriptase inhibitors; nonadvanced HIV infection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Morlat, P CHU Bordeaux, Serv Med Interne & Malad Infect, Hop St Andre, 1 Rue Jean Burguet, F-33075 Bordeaux, France CHU Bordeaux 1 Rue Jean Burguet Bordeaux France F-33075 France
Citazione:
P. Morlat et al., "Dual nucleoside regimens in nonadvanced HIV infection: Prospective follow-up of 130 patients, Aquitaine Cohort, 1996 to 1998", J ACQ IMM D, 23(3), 2000, pp. 255-260

Abstract

Objective: To describe the response to combinations of two nucleoside reverse transcriptase inhibitors (NRTIs) initiated early in the course of HIV infection under routine circumstances and to research prognostic factors indicating good virologic response. Setting: Patients of the Aquitaine Cohort, a hospital-based open cohort that had been recruiting since 1987 in five public hospitals of the Aquitaineregion in southwestern France. Methods: Prospective cohort study of antiretroviral-naive patients with CD4(+) cell counts >0.350 x 10(9)/L who started dual NRTI therapy between January 1996 and June 1997. Intent-to-treat analysis and multivariate logisticregression were used with data collected up to March 31, 1998. Results: In this study, 130 patients were enrolled with a median follow-upof 14 months. At the time of first prescription, 79% were in U. S. Centersfor Disease Control and Prevention (CDC) group A, 16% in group B, and 5% in group C; median CD4(+) cell count was 0.466 x 10(9)/L and median HIV RNA level was 4.52 log(10) copies/ml. The two main combinations used were zidovudine (AZT) plus zalcitabine (ddC; 38%) and AZT plus didanosine (ddI; 37%). At week 52, median CD4(+) and HN RNA responses were, respectively, +80 cells and -1.6 log; the proportions of patients with HIV RNA level <5000 and <500 copies/ml were 70% and 45%, respectively, and 96% of the patients had aCD4(+) cell count >0.350 x 10(9)/L at that time. At their last follow-up, 3 patients had reached been diagnosed with full-blown AIDS and the AIDS-free survival probability at 1 year was 98.2% (95% confidence interval [CI], 93.1-99.6); 1 death had occurred. The only significant variable associated with an undetectable HIV RNA level at 1 year was a lower HIV RNA level at the first prescription of dual therapy. Conclusion: Our data indicate that dual nucleoside combinations could be atherapeutic option for patients diagnosed and observed during follow-up inthe early course of HIV infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/05/20 alle ore 04:27:02