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Titolo:
Biopharmaceutics and pharmacokinetics in drug research
Autore:
Panchagnula, R; Thomas, NS;
Indirizzi:
Natl Inst Pharmaceut Educ & Res, Dept Pharmaceut, Nagar 160062, Punjab, India Natl Inst Pharmaceut Educ & Res Nagar Punjab India 160062 , Punjab, India
Titolo Testata:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
fascicolo: 2, volume: 201, anno: 2000,
pagine: 131 - 150
SICI:
0378-5173(20000525)201:2<131:BAPIDR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
OCTANOL-WATER PARTITION; HIV PROTEASE INHIBITOR; EPITHELIAL-CELL MONOLAYERS; BRUSH-BORDER MEMBRANE; LOG-P; DISTRIBUTION COEFFICIENTS; ORAL BIOAVAILABILITY; MOLECULAR-STRUCTURES; ISOLATED HEPATOCYTES; MATHEMATICAL-MODEL;
Keywords:
new drug development; biopharmaceutics; pharmacokinetics; solubility; permeability; lipophilicity;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
105
Recensione:
Indirizzi per estratti:
Indirizzo: Panchagnula, R Natl Inst Pharmaceut Educ & Res, Dept Pharmaceut, Sector 67, Nagar 160062,Punjab, India Natl Inst Pharmaceut Educ & Res Sector 67 Nagar Punjab India 160062
Citazione:
R. Panchagnula e N.S. Thomas, "Biopharmaceutics and pharmacokinetics in drug research", INT J PHARM, 201(2), 2000, pp. 131-150

Abstract

With the synergistic and multiplicative interactions of rational drug design, recombinant biotechnology, combinatorial chemistry and high-throughput screening, millions of compounds are being synthesized by chemists. However. development of these drug candidates has often been impeded, if not terminated, due to biopharmaceutic and/or pharmacokinetic constraints. This has resulted in delays in development time and escalation of cost in the drug research programmes. So, the present emphasis is to reduce development time and cost, which is analogous to added patent life besides the enormous reduction in human suffering. In this compilation the important biopharmaceuticand pharmacokinetic approaches are discussed, which will help in the development of safe and more efficacious drugs with reduced development time andcost. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 04:56:50