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Titolo:
Hepatitis c virus (HCV) infection in a community in the Nile Delta: Population description and HCV prevalence
Autore:
Abdel-Aziz, F; Habib, M; Mohamed, MK; Abdel-Hamid, M; Gamil, F; Madkour, S; Mikhail, NN; Thomas, D; Fix, AD; Strickland, GT; Anwar, W; Sallam, I;
Indirizzi:
Univ Maryland, Sch Med, Dept Epidemiol & Prevent Med, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 Prevent Med, Baltimore, MD 21201 USA Ain Shams Univ, Cairo, Egypt Ain Shams Univ Cairo EgyptAin Shams Univ, Cairo, Egypt Minia Univ, Menia, Egypt Minia Univ Menia EgyptMinia Univ, Menia, Egypt Assiut Univ, Assiut, Egypt Assiut Univ Assiut EgyptAssiut Univ, Assiut, Egypt Johns Hopkins Med Inst, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 st, Baltimore, MD 21205 USA
Titolo Testata:
HEPATOLOGY
fascicolo: 1, volume: 32, anno: 2000,
pagine: 111 - 115
SICI:
0270-9139(200007)32:1<111:HCV(II>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
VOLUNTEER BLOOD-DONORS; HIGH SEROPREVALENCE; RISK-FACTORS; EGYPT; EPIDEMIOLOGY; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Fix, AD Univ Maryland, Sch Med, Dept Epidemiol & Prevent Med, 660 W Redwood St, Baltimore, MD 21201 USA Univ Maryland 660 W Redwood St Baltimore MD USA 21201 MD 21201 USA
Citazione:
F. Abdel-Aziz et al., "Hepatitis c virus (HCV) infection in a community in the Nile Delta: Population description and HCV prevalence", HEPATOLOGY, 32(1), 2000, pp. 111-115

Abstract

This report describes a cross-sectional survey of the prevalence of antibodies to hepatitis C virus (anti-HCV) in a rural Egyptian community in the Nile Delta. One half of the village households were systematically selected and examined by questionnaire and testing sera for anti-HCV and HCV RNA. Blood samples were obtained from 3,888 (75.4%) of 5,156 residents greater than or equal to 5 years of age; an additional 111 samples were obtained from children younger than 5 years. Overall, 973 (24.3%) of 3,999 residents wereanti-HCV-positive, and the age- and gender-adjusted seroprevalence was 23.7%. Anti-HCV prevalence increased sharply with age! from 9.3% in those 20 years of age and younger to >50% in those older than 35 years. Currently or previously married individuals were more likely to be seropositive than those never married, controlling for age (Mantel-Haenszel risk ratio = 1.8; 95% CI: 1.3, 2.6). Of the 905 anti-HCV-positive samples tested, 65% were alsopositive for HCV RNA. Active schistosomal infection was not associated with anti-HCV status; however, history of antischistosomal injection therapy (reported by 19% of anti-HCV positives) was a risk for anti-HCV (age-adjusted risk ratio = 1.3; 95% CI: 1.2, 1.5). This study, the largest community-based survey to date, supports earlier reports of high levels of anti-HCV among adults in rural areas of Egypt, although many of those who are seropositive will not have active liver disease. The large reservoir of HCV infection in the community provides an opportunity to investigate risk factors for transmission, the natural history of infection and effectiveness of preventive methodologies, and raises concern about the prospect of an increasing incidence of chronic Liver disease in the coming decades.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 15:13:05