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Titolo:
Identification and gene organization of three novel members of the IL-1 family on human chromosome 2
Autore:
Busfield, SJ; Comrack, CA; Yu, G; Chickering, TW; Smutko, JS; Zhou, H; Leiby, KR; Holmgren, LM; Gearing, DP; Pan, Y;
Indirizzi:
Millennium Pharmaceut Inc, Cambridge, MA 02139 USA Millennium Pharmaceut Inc Cambridge MA USA 02139 Cambridge, MA 02139 USA
Titolo Testata:
GENOMICS
fascicolo: 2, volume: 66, anno: 2000,
pagine: 213 - 216
SICI:
0888-7543(20000601)66:2<213:IAGOOT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIATION HYBRID MAP; HUMAN GENOME; RECEPTOR ANTAGONIST; EXPRESSION; HIPPOCAMPUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Busfield, SJ Western Australian Inst Med Res, MRF Bldg,Rear 50 Murray St, Perth, WA 6001, Australia Western Australian Inst Med Res MRF Bldg,Rear 50 Murray St Perth WA Australia 6001
Citazione:
S.J. Busfield et al., "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2", GENOMICS, 66(2), 2000, pp. 213-216

Abstract

Members of the IL-1 family of cytokines are important in mediating inflammatory responses. The genes encoding IL-1 alpha, IL-beta, and the IL-1 receptor antagonist (IL-1Ra) are clustered within 450 kb on human chromosome 2q. By searching the EST databases and sequencing this region of chromosome 2,we have identified three novel genes that show homology to the IL-1 family, which we have named IL-1-related protein 1, 2, and 3 (IL-1RP1, IL-1RP2, and IL-1RP3). All three genes contain a signature motif common to the IL-1 family and appear to be more closely related to IL-1Ra. Similar to the intracellular form of IL-1Ra, these genes lack conventional hydrophobic signal sequences. The expression of these genes appears to be highly restricted to various epithelial cell populations. Our results demonstrate the existence of additional IL-1 gene family members within the previously defined IL-1 cluster and point to this region of chromosome 2 as an evolutionary hotspot for IL-1 gene duplication. These genes may prove to have an important role in inflammatory responses. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 23:17:11