Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Initial results utilizing combination therapy for patients with a suboptimal response to either alprostadil or sildenafil monotherapy
Autore:
Mydlo, JH; Volpe, MA; Macchia, RJ;
Indirizzi:
Suny Downstate Med Sch, Dept Urol, Brooklyn, NY 11203 USA Suny Downstate Med Sch Brooklyn NY USA 11203 Urol, Brooklyn, NY 11203 USA
Titolo Testata:
EUROPEAN UROLOGY
fascicolo: 1, volume: 38, anno: 2000,
pagine: 30 - 34
SICI:
0302-2838(200007)38:1<30:IRUCTF>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERECTILE DYSFUNCTION; INJECTION THERAPY; IMPOTENCE;
Keywords:
erectile dysfunction; alprostadil; sildenafil; questionnaire;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Mydlo, JH Suny Downstate Med Sch, Dept Urol, Box 79,450 Clarkson Ave, Brooklyn, NY 11203 USA Suny Downstate Med Sch Box 79,450 Clarkson Ave Brooklyn NY USA 11203
Citazione:
J.H. Mydlo et al., "Initial results utilizing combination therapy for patients with a suboptimal response to either alprostadil or sildenafil monotherapy", EUR UROL, 38(1), 2000, pp. 30-34

Abstract

Objective: Intraurethral alprostadil and oral sildenafil are useful in selected patients. However, there continues to be a significant treatment failure rate. Since their mechanisms of action are different, we wanted to evaluate the effectiveness of combination therapy. Materials andMethods: Of 214 patients treated for erectile dysfunction (ED), 65 were not fully satisfied with the firmness of their erections via monotherapy. Responses were evaluated using the International index for Erectile Function (IIEF) questionnaire before and after treatment. Group I consisted of 33 patients who tried maximal dose intraurethral alprostadil monotherapy initially, followed by the maximal dose of sildenafil monotherapy, and were still unsatisfied. Group II consisted of 32 patients who tried the maximal dose sildenafil monotherapy initially, followed by the maximal dose of alprostadilmonotherapy, and were also unsatisfied. There 65 patients then underwent combination therapy. Results: 60 out of the 65 patients stated they were satisfied with combination therapy. Questionnaire scores for erectile function were 23.1+/-2.0 (114%) for combination therapy vs. 19.2+/-1.8 (77%) and 15.2+/-1.6 (41%) for sildenafil and alprostadil monotherapies (p<0.05). There were no significant differences in responses between the two groups. The men also reported improvement in intercourse and overall satisfaction. Conclusions: Combination therapy may be an option for motivated patients who have a suboptimal response from monotherapy. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 23:42:33