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Titolo:
A concise and efficient synthesis of [2-methyl-5-methylsulfonyl-4-(pyrrol-1-yl)benzoyl]guanidinium methanesulfonate (eniporide)
Autore:
Baumgarth, M; Gericke, R;
Indirizzi:
Merck KGaA, D-64271 Darmstadt, Germany Merck KGaA Darmstadt Germany D-64271 ck KGaA, D-64271 Darmstadt, Germany
Titolo Testata:
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
fascicolo: 12, , anno: 2000,
pagine: 2253 - 2255
SICI:
1434-193X(200006):12<2253:ACAESO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROGEN EXCHANGE INHIBITION; NA+/H+-EXCHANGE; MYOCARDIAL-ISCHEMIA; GUARDIAN TRIAL; CARIPORIDE; REPERFUSION; INJURY;
Keywords:
Na+/H+ antiporter; eniporide; benzoylguanidine; drug research; synthetic methods;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Gericke, R Merck KGaA, D-64271 Darmstadt, Germany Merck KGaA Darmstadt Germany D-64271 64271 Darmstadt, Germany
Citazione:
M. Baumgarth e R. Gericke, "A concise and efficient synthesis of [2-methyl-5-methylsulfonyl-4-(pyrrol-1-yl)benzoyl]guanidinium methanesulfonate (eniporide)", EUR J ORG C, (12), 2000, pp. 2253-2255

Abstract

A new synthesis of the benzoylguanidine-type Na+/H+ antiporter inhibitor eniporide (7) is described. Starting from 2-bromo-5-fluorotoluene (1), aromatic substituents were introduced by methanesulfonylation, Pd-catalyzed carboxylation with CO, and halogen-pyrrole exchange. Guanidine acylation was performed using Mukaiyama's procedure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 10:20:38