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Titolo:
Comparison of clinical data sets acquired on different tomographs using 6-F-18-L-dopa
Autore:
Ribeiro, MJ; Remy, P; Bendriem, B; Almeida, P; Brulon, V; Samson, Y; Maziere, B; Trebossen, R;
Indirizzi:
Serv Hosp Frederic Joliot, CEA, DSV, DRM, F-91406 Orsay, France Serv Hosp Frederic Joliot Orsay France F-91406 RM, F-91406 Orsay, France Fac Med Coinbra, IBILI, Serv Biofis, Coimbra, Portugal Fac Med Coinbra Coimbra Portugal IBILI, Serv Biofis, Coimbra, Portugal CTI PET Syst Inc, Knoxville, TN USA CTI PET Syst Inc Knoxville TN USACTI PET Syst Inc, Knoxville, TN USA Siemens, Paris, France Siemens Paris FranceSiemens, Paris, France IBEFL, FCL, Lisbon, Portugal IBEFL Lisbon PortugalIBEFL, FCL, Lisbon, Portugal
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 6, volume: 27, anno: 2000,
pagine: 707 - 712
SICI:
0340-6997(200006)27:6<707:COCDSA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; F-18 DOPA-PET; PARKINSONS-DISEASE; PERFORMANCE EVALUATION; SCANNER; 6-FLUORO-L-DOPA; QUANTITATION; CARBIDOPA;
Keywords:
6-18F-L-dopa; positron emission tomography; acquisition modes; reconstruction protocols;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Ribeiro, MJ Serv Hosp Frederic Joliot, CEA, DSV, DRM, 4 Pl Gen Leclerc, F-91406 Orsay,France Serv Hosp Frederic Joliot 4 Pl Gen Leclerc Orsay FranceF-91406
Citazione:
M.J. Ribeiro et al., "Comparison of clinical data sets acquired on different tomographs using 6-F-18-L-dopa", EUR J NUCL, 27(6), 2000, pp. 707-712

Abstract

Longitudinal positron emission tomography (PET) studies of 6-F-18-L-dopa uptake in the striatum are used to assess the progression of Parkinson's disease or the survival of neuronal cells grafted in parkinsonian patients, These studies are performed over several years, and data analysis may suffer from the change from old tomographs to new machines with better sensitivityand spatial resolution. Furthermore, such studies on parkinsonian patientsmay be accomplished in either 2D or 3D acquisition mode. The aforementioned improvements offer gnat benefits for the study of neurodegenerative diseases, especially those affecting the striatum. However, direct comparison ofdata is not straightforward owing to variation in scanner characteristics. In this study, we assessed the feasibility of comparing the 6-F-18-L-dopa striatal uptake values (K-c) measured in two groups of healthy subjects using two tomographs of different generations. We re-studied and compared acquisitions performed on 14 healthy subjects using 6-F-18-L-dopa. Half of these studies had been performed in 2D acquisition mode using an ECAT 953B. Theother half had been performed in 3D acquisition mode using an ECAT EXACT HR+. Different reconstruction protocols were used and the K-c values obtained were statistically compared. The results showed that lowering the transverse spatial resolution of images obtained with the scanner having the better spatial resolution, so that it more closely marched that of the other machine, allowed similar K-c values to be obtained in healthy subjects, This study shows that quantitative results of 6-F-18-L-dopa scans can be matched between different scanners with different intrinsic resolutions. This can be accomplished using adequate modifications of the reconstruction parameters. Such modifications can be used to help in the longitudinal monitoring ofparkinsonian patients using different tomographs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:21:23