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Titolo:
Cardiac fluorine-18 fluorodeoxyglucose imaging using a dual-head gamma camera with coincidence detection: a clinical pilot study
Autore:
De Sutter, J; De Winter, F; Van de Wiele, C; De Bondt, P; DAsseler, Y; Dierckx, R;
Indirizzi:
State Univ Ghent Hosp, Dept Cardiol, B-9000 Ghent, Belgium State Univ Ghent Hosp Ghent Belgium B-9000 ardiol, B-9000 Ghent, Belgium State Univ Ghent Hosp, Dept Nucl Med, B-9000 Ghent, Belgium State Univ Ghent Hosp Ghent Belgium B-9000 cl Med, B-9000 Ghent, Belgium State Univ Ghent, ELIS, MEDISIP, B-9000 Ghent, Belgium State Univ Ghent Ghent Belgium B-9000 IS, MEDISIP, B-9000 Ghent, Belgium
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 6, volume: 27, anno: 2000,
pagine: 676 - 685
SICI:
0340-6997(200006)27:6<676:CFFIUA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; LEFT-VENTRICULAR DYSFUNCTION; CORONARY-ARTERY DISEASE; MYOCARDIAL VIABILITY; F-18 FLUORODEOXYGLUCOSE; HIBERNATING MYOCARDIUM; COMPUTED-TOMOGRAPHY; FDG PET; SPECT; PREDICTION;
Keywords:
myocardial viability; coincidence detection; fluorine-18 fluorodeoxyglucose; single-photon emission tomography; positron emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: De Sutter, J State Univ Ghent Hosp, Dept Cardiol, De Pintelaan 185, B-9000Ghent, Belgium State Univ Ghent Hosp De Pintelaan 185 Ghent Belgium B-9000
Citazione:
J. De Sutter et al., "Cardiac fluorine-18 fluorodeoxyglucose imaging using a dual-head gamma camera with coincidence detection: a clinical pilot study", EUR J NUCL, 27(6), 2000, pp. 676-685

Abstract

Dual-headed gamma cameras with coincidence detection (MCD) are increasingly used for imaging of positron-emitting tracers, such as fluorine-18 fluorodeoxyglucose (FDG). In this study, we examined differences between FDG MCD and FDG positron emission tomography (PET) as the gold standard to determine whether FDG MCD could be used for assessment of myocardial viability in daily practice. Nineteen patients with a previous myocardial infarction (17 men: mean left ventricular ejection fraction 44%+/-13%) underwent FDG MCD, FDG PET, resting echocardiography and technetium-99m tetrofosmin gated single-photon emission tomography (SPET). At the 50% threshold value for FDG PET, the area under the receiver operating characteristic curve for FDG MCD was 0.77+/-0.03, In 107 dyssynergic segments on echocardiography and 151 segments with hypoperfusion on Tc-99m-tetrofosmin SPET. the specificity of FDGMCD for the detection of myocardial viability was 72% and 76% respectively, with a sensitivity of 69% and 72% respectively. Regional analysis showed a significantly lower agreement of FDG MCD and FDG PET in the inferior and septal regions (58% for dyssynergic segments and 65% for segments with hypoperfusion), as compared with the other regions (85% for dyssynergic regions, P<0.05, and 86% for segments with hypoperfusion, P<0.05). Five patients (26%). who all had a body mass index greater than or equal to 25% kg/m(2), showed more than 25% disagreement between FDG MCD and FDG PET. Because of the moderate overall agreement with FDG; PET, the low sensitivity in akineticor dyskinetic regions and the low agreement in the inferior and septal regions, further studies and implementations of technical developments are needed before FDG MCD can be introduced into clinical practice for the assessment of myocardial viability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 08:50:57