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Titolo:
Expression of Fos-related antigens in the nucleus accumbens and associatedregions following exposure to a cocaine-paired environment
Autore:
Franklin, TR; Druhan, JP;
Indirizzi:
MCPHU, Grad Program Neurosci, Philadelphia, PA 19102 USA MCPHU Philadelphia PA USA 19102 gram Neurosci, Philadelphia, PA 19102 USA Univ Penn, Sch Med, Dept Psychiat, Ctr Neurobiol & Behav, Philadelphia, PA19104 USA Univ Penn Philadelphia PA USA 19104 ol & Behav, Philadelphia, PA19104 USA
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 6, volume: 12, anno: 2000,
pagine: 2097 -
SICI:
0953-816X(200006)12:6<2097:EOFAIT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONED PLACE PREFERENCE; MEDIAL PREFRONTAL CORTEX; DOPAMINE OXIDATION CURRENTS; INDUCED LOCOMOTOR-ACTIVITY; RAT VENTRAL STRIATUM; PAVLOVIAN HEART-RATE; D-AMPHETAMINE; C-FOS; BASOLATERAL AMYGDALA; INDUCED HYPERACTIVITY;
Keywords:
c-fos; cingulate cortex; conditioned responses; drug abuse; nucleus accumbens; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Druhan, JP Vet Adm Med Ctr, Mail Code 151,Univ & Woodland Ave, Philadelphia, PA 19104USA Vet Adm Med Ctr Mail Code 151,Univ & Woodland Ave Philadelphia PA USA 19104
Citazione:
T.R. Franklin e J.P. Druhan, "Expression of Fos-related antigens in the nucleus accumbens and associatedregions following exposure to a cocaine-paired environment", EUR J NEURO, 12(6), 2000, pp. 2097

Abstract

This study examined whether conditioned hyperactivity measured in a cocaine-paired environment was associated with increased expression of Fos-related antigens (FRA) within the nucleus accumbens (NAc) and associated forebrain regions of rats. Three groups of rats were given repeated injections of either cocaine in the test environment and saline in the colony room (group Paired), saline in the test environment and cocaine in the colony room (group Unpaired), or saline in both environments (group Control). All rats weresubsequently given a drug-free test for conditioned hyperactivity in the test environment, and their brains were removed so that FRA immunohistochemistry could be conducted. Rats in the Paired group showed conditioned hyperactivity during the conditioning test, and this behavioural response was associated with increased FRA expression within the caudal NAc, the medial prefrontal cortex and the lateral septum relative to the Unpaired and Control groups. Paired rats also showed increased FRA expression within the orbitalprefrontal cortex, the claustrum, the caudal amygdala (basolateral and central regions), the paraventricular thalamic nucleus, the subiculum of the hippocampus, and the lateral habenula relative to the Control group. However, the FRA levels in these latter sites were not significantly increased relative to those of Unpaired rats, indicating that genomic responses in theseregions were not entirely context dependent. The correspondence between conditioned hyperactivity and enhanced FRA expression within the caudal NAc, the medial prefrontal cortex and lateral septum suggests that these regionsmay participate in the expression of conditioned responses to cocaine-related stimuli.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:07:21