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Titolo:
Cloning and characterization of SDF-1 gamma a novel SDF-1 chemokine transcript with developmentally regulated expression in the nervous system
Autore:
Gleichmann, M; Gillen, C; Czardybon, M; Bosse, F; Greiner-Petter, R; Auer, J; Muller, HW;
Indirizzi:
Univ Dusseldorf, Dept Neurol, Mol Neurobiol Lab, D-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany Univ Dusseldorf, Biomed Res Ctr, D-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany Roche Diagnost GmbH, Pharma Res, Mannheim, Germany Roche Diagnost GmbH Mannheim Germany mbH, Pharma Res, Mannheim, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 6, volume: 12, anno: 2000,
pagine: 1857 - 1866
SICI:
0953-816X(200006)12:6<1857:CACOSG>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR CXCR4; FACTOR-I; CELLS; HIV-1; CHEMOATTRACTANT; LYMPHOPOIESIS; MYELOPOIESIS; LESTR/FUSIN; PROTEINS; LIGAND;
Keywords:
CXC chemokine; neuron; rat; Schwann cell; stromal cell-derived factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Muller, HW Univ Dusseldorf, Dept Neurol, Mol Neurobiol Lab, Moorenstr 5, D-40225 Dusseldorf, Germany Univ Dusseldorf Moorenstr 5 Dusseldorf Germany D-40225 Germany
Citazione:
M. Gleichmann et al., "Cloning and characterization of SDF-1 gamma a novel SDF-1 chemokine transcript with developmentally regulated expression in the nervous system", EUR J NEURO, 12(6), 2000, pp. 1857-1866

Abstract

The cytokines SDF-1 alpha and -1 beta are two alternatively spliced variants of the CXC (alpha) chemokines that are highly conserved among species. SDF-1 alpha was shown to function as a B-cell maturation factor, a ligand for the CXCR4 (LESTR/fusin) chemokine receptor, thereby inhibiting replication of T cell-tropic HIV-1 strains and inducing cell death in human neuronal cell lines. In this report the cloning of the rat SDF-1 beta cDNA and a newSDF-1 isoform, SDF-1 gamma, are presented. Using Northern blot analysis, the expression pattern of both isoforms was studied in different tissues andit is shown that during postnatal development of the central and peripheral nervous system SDF-1 beta- and SDF-1 gamma-mRNA expression is inversely regulated. Whilst SDF-1 beta-mRNA is the predominant isoform in embryonic and early postnatal nerve tissue, SDF-1 gamma-mRNA is expressed at higher levels in adulthood. After peripheral nerve lesion a transient increase in SDF-1 beta-mRNA expression is observed. As revealed by in situ hybridization, neurons and Schwann cells are the main cellular sources of both SDF-1 beta and SDF-1 gamma mRNAs in the nervous system. Computer-assisted analysis revealed that both transcripts encode secreted peptides with putative proteolytic cleavage sites which might generate novel neuropeptides.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 15:46:47