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Titolo:
Lipid metabolism in the fetus and the newborn
Autore:
Herrera, E; Amusquivar, E;
Indirizzi:
Univ San Pablo, CEU, Fac Ciencias Expt & Tecn, E-28668 Madrid, Spain Univ San Pablo Madrid Spain E-28668 s Expt & Tecn, E-28668 Madrid, Spain
Titolo Testata:
DIABETES-METABOLISM RESEARCH AND REVIEWS
fascicolo: 3, volume: 16, anno: 2000,
pagine: 202 - 210
SICI:
1520-7552(200005/06)16:3<202:LMITFA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPOPROTEIN-LIPASE ACTIVITY; LATE PREGNANT RAT; SYNTHASE GENE-EXPRESSION; ESSENTIAL FATTY-ACIDS; WHITE ADIPOSE-TISSUE; INSULIN-RESISTANCE; POSTNATAL-DEVELOPMENT; APOLIPOPROTEIN-E; BINDING PROTEIN; CLAMP TECHNIQUE;
Keywords:
fetal; metabolism; adipose tissue; essential fatty acids; ketone bodies; suckling; diabetes;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
121
Recensione:
Indirizzi per estratti:
Indirizzo: Herrera, E Univ San Pablo, CEU, Fac Ciencias Expt & Tecn, Urb Monteprincipe,Ctra Boadilla Monte Km 5-3, E-28668 Madrid, Spain Univ San Pablo Urb Monteprincipe,Ctra Boadilla Monte Km 5-3 Madrid Spain E-28668
Citazione:
E. Herrera e E. Amusquivar, "Lipid metabolism in the fetus and the newborn", DIABET M R, 16(3), 2000, pp. 202-210

Abstract

During late gestation, although maternal adipose tissue lipolytic activitybecomes enhanced, lipolytic products cross the placenta with difficulty. Under fasting conditions, free fatty acids (FFA) are used for ketogenesis bythe mother, and ketone bodies are used as fuels and lipogenic substrates by the fetus. Maternal glycerol is preferentially used for glucose synthesis, saving other gluconeogenic substrates, like amino acids, for fetal growth. Placental transfer of triglycerides is null, but essential fatty acids derived from maternal diet, which are transported as triglycerides in lipoproteins, become available to the fetus owing to the presence of both lipoprotein receptors and lipase activities in the placenta. Diabetes in pregnancy promotes lipid transfer to the fetus by increasing the maternal-fetal gradient, which may contribute to an increase in body fat mass in newborns of diabetic women. Deposition of fat stores in the fetus is very low in the rat but high in humans, where body fat accretion occurs essentially during the last trimester of intra-uterine life. This is sustained by the intense placental transfer of glucose and by its use as a lipogenic substrate, as well as by the placental transfer of fatty acids and to their low oxidation activity. During the perinatal period an active ketonemia develops, which is maintained in the suckling newborn by several factors: (i) the high-fat and low-carbohydrate content in milk, (ii) the enhanced lipolytic activity occurring during the first few hours of life, and (iii) both the uptake of circulating triglycerides by the liver due to the induction of lipoprotein lipase (LPL) activity in this organ, and the presence of ketogenic activity in the intestinal mucose. Changes in LPL activity, lipogenesis and lipolysis contribute to the sequential steps of adipocyte hyperplasia and hypertrophia occurring during the extra-uterine white adipose tissue development in rat,and this may be used as a model to extrapolate the intra-uterine adipose tissue development in other species, including humans. Copyright (C) 2000 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 06:14:23