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Titolo:
Biological and behavioural determinants of the frequency of mild, biochemical hypoglycaemia in patients with Type 1 diabetes on multiple insulin injection therapy
Autore:
Janssen, MMJ; Snoek, FJ; de Jongh, RT; Casteleijn, S; Deville, W; Heine, RJ;
Indirizzi:
Free Univ Amsterdam Hosp, Dept Endocrinol, Res Inst Endocrinol Reprod & Metab, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp AmsterdamNetherlands NL-1007 MB m, Netherlands Free Univ Amsterdam, Fac Med, Dept Epidemiol & Biostat, NL-1081 BT Amsterdam, Netherlands Free Univ Amsterdam Amsterdam Netherlands NL-1081 BT terdam, Netherlands
Titolo Testata:
DIABETES-METABOLISM RESEARCH AND REVIEWS
fascicolo: 3, volume: 16, anno: 2000,
pagine: 157 - 163
SICI:
1520-7552(200005/06)16:3<157:BABDOT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE HYPOGLYCEMIA; IDDM; AWARENESS; ADULTS; RISK; UNAWARENESS; MELLITUS;
Keywords:
hypoglycaemia; Type 1 diabetes mellitus; multiple insulin injection therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Heine, RJ Free Univ Amsterdam Hosp, Dept Endocrinol, Res Inst Endocrinol Reprod & Metab, POB 7057, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp POB 7057 Amsterdam Netherlands NL-1007 MB
Citazione:
M.M.J. Janssen et al., "Biological and behavioural determinants of the frequency of mild, biochemical hypoglycaemia in patients with Type 1 diabetes on multiple insulin injection therapy", DIABET M R, 16(3), 2000, pp. 157-163

Abstract

Background Severe hypoglycaemic episodes are an important source of morbidity in people with Type 1 diabetes. The occurrence of severe hypoglycaemia is strongly related to the frequency of low blood glucose readings. The aimof this exploratory study was to identify determinants of the frequency ofmild, biochemical hypoglycaemia in patients with Type I diabetes treated with multiple insulin injection therapy. Methods We studied 31 patients with Type 1 diabetes in reasonable glycaemic control (HbA(1c)less than or equal to 8.3%) during multiple injection therapy. The study had a prospective, observational design. We used standardised home blood glucose monitoring (HBGM) diaries to assess the frequency of hypoglycaemia (HBGM readings<3.5 mmol/L) over a period of 6 weeks. Potential determinants studied included biological factors, self-management factors(including weekly total physical activity and vigorous physical activity),psychological factors (including psychological distress) and mediating factors [average and standard deviation (SD) of the HBGM readings and self-reported hypoglycaemia awareness]. Results Determinants of mild hypoglycaemia frequency identified in univariate regression analyses were: SD and mean of HBGM (beta 0.6, p = 0.001 and beta -0.6, p = 0.001), diabetes duration (beta 0.5, p = 0.008) and self-reported hypoglycaemia unawareness (beta -0.5, p = 0.003). A trend was observed for performance of vigorous physical activities (beta 0.3, p = 0.06) and external eating behaviour (beta -0.3, p = 0.1). These relations were confirmed in multivariate analyses. Conclusions Patients with Type I diabetes who have a high blood glucose variability and low average blood glucose concentration, diabetes of long duration, low body mass index, self-reported impaired awareness of hypoglycaemia and those participating in vigorous physical activities, specifically require interventions aimed at preventing hypoglycaemia. Copyright (C) 2000 John Wiley & Sons, Ltd.

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Documento generato il 04/04/20 alle ore 08:54:57