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Titolo:
No major association of breast-feeding, vaccinations, and childhood viral diseases with early islet autoimmunity in the German BABYDIAB study
Autore:
Hummel, M; Fuchtenbusch, M; Schenker, M; Ziegler, AG;
Indirizzi:
Diabet Res Inst, D-80804 Munich, Germany Diabet Res Inst Munich Germany D-80804 Res Inst, D-80804 Munich, Germany Hosp Munchen Schwabing, Dept Med 3, Munich, Germany Hosp Munchen Schwabing Munich Germany bing, Dept Med 3, Munich, Germany
Titolo Testata:
DIABETES CARE
fascicolo: 7, volume: 23, anno: 2000,
pagine: 969 - 974
SICI:
0149-5992(200007)23:7<969:NMAOBV>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-CELL AUTOIMMUNITY; COWS MILK; DIABETES-MELLITUS; PARENTS; AUTOANTIBODIES; ANTIBODIES; EXPOSURE; CHILDREN; PROTEIN; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Ziegler, AG Diabet Res Inst, Kolner Pl 1, D-80804 Munich, Germany Diabet Res Inst Kolner Pl 1 Munich Germany D-80804 h, Germany
Citazione:
M. Hummel et al., "No major association of breast-feeding, vaccinations, and childhood viral diseases with early islet autoimmunity in the German BABYDIAB study", DIABET CARE, 23(7), 2000, pp. 969-974

Abstract

OBJECTIVE - Environmental factors have been suggested to play an importantrole in the pathogenesis of type 1 diabetes. The aim of this study was to assess the influence of breast-feeding, vaccinations, and childhood viral diseases on the initiation of islet autoimmunity in early childhood. RESEARCH DESIGN AND METHODS - Data were prospectively collected from questionnaires obtained at birth, at 9 months of age, and at 2 years of age in 823 offspring from parents with type 1 diabetes. By 2 years of age, 31 offspring had islet antibodies, and 10 developed overt diabetes by the time of follow-up. RESULTS - In offspring from mothers with type 1 diabetes, duration of exclusive and total breast-feeding did not differ between islet antibody-positive and -negative children, regardless of HLA genotype, and breast-feeding of 3 months or longer was not associated with protection from antibody development or diabetes onset. In offspring from diabetic fathers, non-statistically significant reductions in exclusive and total breast-feeding times were observed in the antibody-positive cohort. Neither type nor quantity of vaccinations (including Bacille Calmette-Guerin vaccine; haemophilus influenzae vaccine; diphtheria, tetanus, and pertussis vaccine; tick-born encephalitis vaccine; or measles, mumps, and rubella vaccine) were associated with the development of islet antibodies and diabetes. Measles, mumps, and rubella were not reported in children with islet antibodies or diabetes. CONCLUSIONS - This study showed no evidence that proposed environmental factors affect islet antibody development in the first 2 years of life in offspring from parents with type 1 diabetes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:02:58