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Titolo:
Molecular analysis of external genitalia formation: the role of fibroblastgrowth factor (Fgf) genes during genital tubercle formation
Autore:
Haraguchi, R; Suzuki, K; Murakami, R; Sakai, M; Kamikawa, M; Kengaku, M; Sekine, K; Kawano, H; Kato, S; Ueno, N; Yamada, G;
Indirizzi:
Kumamoto Univ, CARD, Kumamoto 8600811, Japan Kumamoto Univ Kumamoto Japan 8600811 Univ, CARD, Kumamoto 8600811, Japan Kurume Univ, Res Ctr Innovat Canc Therapy, Kurume, Fukuoka 830, Japan Kurume Univ Kurume Fukuoka Japan 830 Therapy, Kurume, Fukuoka 830, Japan Yamaguchi Univ, Dept Phys Biol & Informat, Yamaguchi 7538512, Japan Yamaguchi Univ Yamaguchi Japan 7538512 nformat, Yamaguchi 7538512, Japan Kyoto Univ, Fac Sci, Dept Biophys, Sakyo Ku, Kyoto 6068502, Japan Kyoto Univ Kyoto Japan 6068502 t Biophys, Sakyo Ku, Kyoto 6068502, Japan Univ Tokyo, Inst Mol & Cellular Biosci, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 l & Cellular Biosci, Tokyo 1130033, Japan Natl Inst Basic Biol, Dept Dev Biol, Okazaki, Aichi 4448585, Japan Natl Inst Basic Biol Okazaki Aichi Japan 4448585 ki, Aichi 4448585, Japan
Titolo Testata:
DEVELOPMENT
fascicolo: 11, volume: 127, anno: 2000,
pagine: 2471 - 2479
SICI:
0950-1991(200006)127:11<2471:MAOEGF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPITHELIAL-MESENCHYMAL INTERACTIONS; MORPHOGENETIC PROTEIN-4 BMP-4; UROGENITAL SINUS MESENCHYME; APICAL ECTODERMAL RIDGE; LIMB DEVELOPMENT; SONIC HEDGEHOG; TARGETED DISRUPTION; TOOTH DEVELOPMENT; VERTEBRATE LIMB; MOUSE EMBRYO;
Keywords:
Fgf8; Fgf10; Msx1; Hox; Bmp4; genital tubercle; clitoris; penis; limb; AER; epithelial-mesenchymal interaction; gene knockout mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
91
Recensione:
Indirizzi per estratti:
Indirizzo: Yamada, G Kumamoto Univ, CARD, Honjo 2-2-1, Kumamoto 8600811, Japan Kumamoto Univ Honjo 2-2-1 Kumamoto Japan 8600811 8600811, Japan
Citazione:
R. Haraguchi et al., "Molecular analysis of external genitalia formation: the role of fibroblastgrowth factor (Fgf) genes during genital tubercle formation", DEVELOPMENT, 127(11), 2000, pp. 2471-2479

Abstract

The molecular mechanisms underlying the development of the external genitalia in mammals have been very little examined. Recent gene knockout studieshave suggested that the developmental processes of its anlage, the genitaltubercle (GT), have much in common with those of limb buds. The Fgf genes have been postulated as regulating several downstream genes during organogenesis. Fgf8 was expressed in the distal urethral plate epithelium of the genital tubercle (GT) together with other markers such as the Msx1, Fgf10, Hoxd13 and Bmp4 expressed in the mesenchyme. To analyze the role of the FGF system during GT formation, an in vitro organ culture system was utilized. It is suggested that the distal urethral plate epithelium of GT, the Fgf8-expressing region, regulates the outgrowth of GT. Ectopic application of FGF8beads to the murine GT induced mesenchymal gene expression, and also promoted the outgrowth of the GT. Experiments utilizing anti-FGF neutralizing antibody suggested a growth-promoting role for FGF protein(s) in GT outgrowth. In contrast, despite its vital role during limb-bud formation, Fgf10 appears not to be primarily essential for initial outgrowth of GT, as extrapolated from Fgf10(-/-) GTs, However, the abnormal external genitalia development of Fgf10(-/-) perinatal mice suggested the importance of Fgf10 in the development of the glans penis and the glans clitoridis. These results suggest that the FGF system is a key element in orchestrating GT development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 20:57:48