Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Glycerophospholipids in brain: their metabolism, incorporation into membranes, functions, and involvement in neurological disorders
Autore:
Farooqui, AA; Horrocks, LA; Farooqui, T;
Indirizzi:
Ohio State Univ, Dept Mol & Cellular Biochem, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 lar Biochem, Columbus, OH 43210 USA
Titolo Testata:
CHEMISTRY AND PHYSICS OF LIPIDS
fascicolo: 1, volume: 106, anno: 2000,
pagine: 1 - 29
SICI:
0009-3084(200006)106:1<1:GIBTMI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET-ACTIVATING-FACTOR; PHOSPHOLIPASE A(2) ACTIVITY; PROTEIN-KINASE-C; CTP-PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE; POLYUNSATURATED FATTY-ACIDS; LONG-TERM POTENTIATION; CANNABINOID-RECEPTOR-LIGAND; CHRONIC LITHIUM TREATMENT; ALZHEIMERS-DISEASE BRAIN; TUMOR-NECROSIS-FACTOR;
Keywords:
glycerophospholipids; phospholipases A(1), A(2), C, and D; arachidonic acid; docosahexaenoic acid; platelet activating factor; diacylglycerol; cannabinoid receptors; membrane fluidity; membrane permeability; apoptosis; neurological disorders;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
221
Recensione:
Indirizzi per estratti:
Indirizzo: Horrocks, LA Ohio State Univ, Dept Mol & Cellular Biochem, 1645 Neil Ave,465 Hamilton Hall, Columbus, OH 43210 USA Ohio State Univ 1645 Neil Ave,465 Hamilton Hall Columbus OH USA 43210
Citazione:
A.A. Farooqui et al., "Glycerophospholipids in brain: their metabolism, incorporation into membranes, functions, and involvement in neurological disorders", CHEM PHYS L, 106(1), 2000, pp. 1-29

Abstract

Neural membranes contain several classes of glycerophospholipids which turnover at different rates with respect to their structure and localization in different cells and membranes. The glycerophospholipid composition of neural membranes greatly alters their functional efficacy. The length of glycerophospholipid acyl chain and the degree of saturation are important determinants of many membrane characteristics including the formation of lateral domains that are rich in polyunsaturated fatty acids. Receptor-mediated degradation of glycerophospholipids by phospholipases A(1), A(2), C, and D results in generation of second messengers such as arachidonic acid, eicosanoids, platelet activating factor and diacylglycerol. Thus, neural membrane phospholipids are a reservoir for second messengers. They are also involved in apoptosis, modulation of activities of transporters, and membrane-bound enzymes. Marked alterations in neural membrane glycerophospholipid composition have been reported to occur in neurological disorders. These alterationsresult in changes in membrane fluidity and permeability. These processes along with the accumulation of lipid peroxides and compromised energy metabolism may be responsible for the neurodegeneration observed in neurological disorders. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:06:21