Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Recent insights on RNA folding mechanisms from catalytic RNA
Autore:
Woodson, SA;
Indirizzi:
Johns Hopkins Univ, TC Jenkins Dept Biophys, Baltimore, MD 21218 USA JohnsHopkins Univ Baltimore MD USA 21218 iophys, Baltimore, MD 21218 USA
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 5, volume: 57, anno: 2000,
pagine: 796 - 808
SICI:
1420-682X(200005)57:5<796:RIORFM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROUP-I INTRON; SELF-SPLICING RNA; PROGRAMMED CELL-DEATH; RIBONUCLEASE-P RNA; PRE-MESSENGER-RNA; ESCHERICHIA-COLI; TETRAHYMENA RIBOZYME; TERTIARY STRUCTURE; SECONDARY STRUCTURE; BACILLUS-SUBTILIS;
Keywords:
RNA folding; ribozyme; energy landscape; translation attenuation; RNA structure; group I intron; RNase P; folding kinetics; transcription elongation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
155
Recensione:
Indirizzi per estratti:
Indirizzo: Woodson, SA Johns Hopkins Univ, TC Jenkins Dept Biophys, 3400 N Charles St, Baltimore,MD 21218 USA Johns Hopkins Univ 3400 N Charles St Baltimore MD USA 21218 SA
Citazione:
S.A. Woodson, "Recent insights on RNA folding mechanisms from catalytic RNA", CELL MOL L, 57(5), 2000, pp. 796-808

Abstract

Methods for probing RNA structure in real time have revealed that initial folding steps are complete in less than a second. Refolding of large catalytic RNAs in vitro often results in long-lived intermediates that reach the native structure very slowly. These kinetically trapped intermediates arisefrom alternative secondary structures that form early in the folding process. In cells, proteins modulate the outcome of RNA folding reactions by stabilizing specific conformations or by accelerating refolding of misfolded intermediates. At the same time, competition between metastable conformations provides a means for regulating the biological activity of transcripts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:52:45