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Titolo:
Sphingosine-1-phosphate and lysophosphatidic acid trigger invasion of primitive hematopoietic cells into stromal cell layers
Autore:
Yanai, N; Matsui, N; Furusawa, T; Okubo, T; Obinata, M;
Indirizzi:
Tohoku Univ, Inst Dev Aging & Canc, Dept Cell Biol, Aoba Ku, Sendai, Miyagi 9808575, Japan Tohoku Univ Sendai Miyagi Japan 9808575 Ku, Sendai, Miyagi 9808575, Japan
Titolo Testata:
BLOOD
fascicolo: 1, volume: 96, anno: 2000,
pagine: 139 - 144
SICI:
0006-4971(20000701)96:1<139:SALATI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
COUPLED RECEPTOR EDG-1; BONE-MARROW CULTURES; T-LYMPHOMA CELLS; STEM-CELLS; IN-VITRO; PROGENITOR CELLS; ADP-RIBOSYLATION; CFU-S; PROTEIN; MAINTENANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Yanai, N Tohoku Univ, Inst Dev Aging & Canc, Dept Cell Biol, Aoba Ku, Seiryo Machi,Sendai, Miyagi 9808575, Japan Tohoku Univ Seiryo Machi Sendai Miyagi Japan 9808575 08575, Japan
Citazione:
N. Yanai et al., "Sphingosine-1-phosphate and lysophosphatidic acid trigger invasion of primitive hematopoietic cells into stromal cell layers", BLOOD, 96(1), 2000, pp. 139-144

Abstract

A new primitive hematopoietic cell line (THS119), exhibiting Lin(-)/Sca-1()/c-Kit(+) a surface phenotype, grew and survived underneath stromal cells(TBR59). The ability of the THS119 cells to invade these stromal cell layers was dependent on the inclusion of serum in the culture medium, This was apparently due to a requirement for lipids contained in serum. Their invasion of the stromal cell layers in serum-free cultures could be triggered by addition of sphingosine-1-phosphate (S1P) or lysophosphatidic acid (LPA) and was dependent on both Rho- and Ras-signaling pathways. Between the 2 possible receptors of S1P and LPA, edg-1 and edg-2, expression of edg-2 only was found to be correlated with immaturity and/or invasive activity of the primitive hematopoietic cells. These results suggest the importance of specific lipids and their specific receptors on the invasive activity of primitive hematopoietic cells in the hematopoietic microenvironment. (Blood. 2000;96:139-144) (C) 2000 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 19:09:41