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Titolo:
Fates of human B-cell precursors
Autore:
LeBien, TW;
Indirizzi:
Univ Minnesota, Ctr Canc, Dept Lab Med & Pathol, Minneapolis, MN 55455 USAUniv Minnesota Minneapolis MN USA 55455 Pathol, Minneapolis, MN 55455 USA Univ Minnesota, Ctr Immunol, Minneapolis, MN USA Univ Minnesota Minneapolis MN USA sota, Ctr Immunol, Minneapolis, MN USA
Titolo Testata:
BLOOD
fascicolo: 1, volume: 96, anno: 2000,
pagine: 9 - 23
SICI:
0006-4971(20000701)96:1<9:FOHBP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE LYMPHOBLASTIC-LEUKEMIA; HUMAN-BONE-MARROW; X-LINKED AGAMMAGLOBULINEMIA; SURROGATE LIGHT-CHAIN; HUMAN CORD-BLOOD; IMMUNOGLOBULIN GENE REARRANGEMENT; RECEPTOR-GAMMA CHAIN; SEVERE COMBINED IMMUNODEFICIENCY; DEFECTIVE LYMPHOID DEVELOPMENT; CHIMERIC TRANSCRIPTION FACTOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
219
Recensione:
Indirizzi per estratti:
Indirizzo: LeBien, TW Univ Minnesota, Ctr Canc, Dept Lab Med & Pathol, 420 Delaware St SE,Box 806 Mayo, Minneapolis, MN 55455 USA Univ Minnesota 420 Delaware StSE,Box 806 Mayo Minneapolis MN USA 55455
Citazione:
T.W. LeBien, "Fates of human B-cell precursors", BLOOD, 96(1), 2000, pp. 9-23

Abstract

Development of mammalian B-lineage cells is characterized by progression through a series of checkpoints defined primarily by rearrangement and expression of immunoglobulin genes. Progression through these checkpoints is also influenced by stromal cells in the microenvironment of the primary tissues wherein B-cell development occurs, ie, fetal liver and bone marrow and adult bone marrow. This review focuses on the developmental biology of human bone marrow B-lineage cells, Including perturbations that contribute to theorigin and evolution of B-lineage acute lymphoblastic leukemia and primaryimmunodeficiency diseases characterized by agammaglobulinemia. Recently described in vitro and in vivo models that support development and expansion of human B-lineage cells through multiple checkpoints provide new tools foridentifying the bone marrow stromal cell-derived molecules necessary for survival and proliferation. Mutations in genes encoding subunits of the pre-B cell receptor and molecules involved in pre-B cell receptor signaling culminate in X-linked and non-X-linked agammaglobulinemia. A cardinal feature of these immunodeficiencies is an apparent apoptotic sensitivity of B-lineage cells at the pro-B to pre-B transition. On the other end of the spectrumis the apoptotic resistance that accompanies the development of B-lineage acute lymphoblastic leukemia, potentially a reflection of genetic abnormalities that subvert normal apoptotic programs. The triad of laboratory modelsthat mimic the bone marrow microenvironment, immunodeficiency diseases with specific defects in B-cell development, and B-lineage acute lymphoblasticleukemia can now be integrated to deepen our understanding of human B-celldevelopment. (Blood. 2000; 96:9-23) (C) 2000 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:01:10