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Titolo:
Association between depression and mortality in older adults - The Cardiovascular Health Study
Autore:
Schulz, R; Beach, SR; Ives, DG; Martire, LM; Ariyo, AA; Kop, WJ;
Indirizzi:
Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 sychiat, Pittsburgh, PA 15260 USA Univ Pittsburgh, Univ Ctr Social & Urban Res, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 ban Res, Pittsburgh, PA 15260 USA Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 idemiol, Pittsburgh, PA 15260 USA Univ Calif Davis, Med Ctr, Dept Cardiol, Sacramento, CA 95817 USA Univ Calif Davis Sacramento CA USA 95817 ardiol, Sacramento, CA 95817 USA Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Washington, DC USA Uniformed Serv Univ Hlth Sci Washington DC USA ychol, Washington, DC USA Georgetown Univ, Med Ctr, Div Cardiol, Washington, DC 20007 USA GeorgetownUniv Washington DC USA 20007 Cardiol, Washington, DC 20007 USA
Titolo Testata:
ARCHIVES OF INTERNAL MEDICINE
fascicolo: 12, volume: 160, anno: 2000,
pagine: 1761 - 1768
SICI:
0003-9926(20000626)160:12<1761:ABDAMI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATE-LIFE DEPRESSION; COMMUNITY SAMPLE; 5-YEAR MORTALITY; MAJOR DEPRESSION; ILL INPATIENTS; FOLLOW-UP; SYMPTOMS; RISK; PREDICTOR; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Schulz, R Univ Pittsburgh, Dept Psychiat, 121 Univ Pl, Pittsburgh, PA 15260 USA Univ Pittsburgh 121 Univ Pl Pittsburgh PA USA 15260 PA 15260 USA
Citazione:
R. Schulz et al., "Association between depression and mortality in older adults - The Cardiovascular Health Study", ARCH IN MED, 160(12), 2000, pp. 1761-1768

Abstract

Background: Studies of the association between depressive symptoms and mortality in elderly populations have yielded contradictory findings. To address these discrepancies, we test this association using the most extensive array of sociodemographic and physical health control variables ever studied, to our knowledge, in a large population-based sample of elderly individuals. Objective: To examine the relation between baseline depressive symptoms and 6-year all-cause mortality in older persons, systematically controlling for sociodemographic factors, clinical disease, subclinical disease, and health risk factors. Methods: A total of 5201 men and women aged 65 years and older from 4 US communities participated in the study. Depressive symptoms and 4 categories of covariates were assessed at baseline. The primary outcome measure was B-year mortality. Results: Of the 5201 participants, 984 (18.9%) died within 6 years. High baseline depressive symptoms were associated with a higher mortality rate (23.9%) than low baseline depression scores (17.7%) (unadjusted relative risk[RR], 1.41; 95% confidence interval [CI], 1.22-1.63). Depression was also an independent predictor of mortality when controlling for sociodemographicfactors (RR, 1.43; 95% CI, 1.23-1.66), prevalent clinical disease (RR, 1.25; 95% CI, 1.07-1.45), subclinical disease indicators (RR, 1.35; 95% CI, 1.15-1.58), or biological or behavioral risk factors (RR, 1.42; 95% CI, 1.22-1.65). When the best predictors from all 4 classes of variables were included as covariates, high depressive symptoms remained an independent predictor of mortality (RR, 1.24; 95% CI, 1.06-1.46). Conclusions: High levels of depressive symptoms are an independent risk factor for mortality in community-residing older adults. Motivational depletion may be a key underlying mechanism for the depression-mortality effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 11:43:58