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Titolo:
Gonadal steroid receptors in the regulation of GnRH secretion in farm animals
Autore:
Scott, CJ; Tilbrook, AJ; Rawson, JA; Clarke, IJ;
Indirizzi:
Monash Univ, Dept Physiol, Clayton, Vic 3168, Australia Monash Univ Clayton Vic Australia 3168 siol, Clayton, Vic 3168, Australia Prince Henrys Inst Med Res, Clayton, Vic 3168, Australia Prince Henrys Inst Med Res Clayton Vic Australia 3168 Vic 3168, Australia
Titolo Testata:
ANIMAL REPRODUCTION SCIENCE
, volume: 60, anno: 2000,
pagine: 313 - 326
SICI:
0378-4320(20000702)60:<313:GSRITR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GONADOTROPIN-RELEASING-HORMONE; MEDIAL PREOPTIC AREA; LUTEINIZING-HORMONE; ESTROGEN-RECEPTOR; TYROSINE-HYDROXYLASE; IMMUNOREACTIVE CELLS; FEMALE SHEEP; OVARIECTOMIZED EWE; CONTAINING NEURONS; BRAIN-STEM;
Keywords:
gonadotrophin-releasing hormone; oestrogen receptor; progesterone receptor; androgen receptor; sheep;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Scott, CJ Monash Univ, Dept Physiol, Wellington Rd, Clayton, Vic 3168, Australia Monash Univ Wellington Rd Clayton Vic Australia 3168 , Australia
Citazione:
C.J. Scott et al., "Gonadal steroid receptors in the regulation of GnRH secretion in farm animals", ANIM REPROD, 60, 2000, pp. 313-326

Abstract

The sites of action and mechanisms by which gonadal steroids regulate gonadotrophin-releasing hormone (GnRK) in domestic animals remain largely unknown. This review summarises information gained from sheep regarding the distribution of the gonadal steroid receptors in the brain, the neurochemical identity and the projections of these steroid receptor-containing neurones. The cells in the hypothalamus that contain each of the gonadal steroid receptors (oestrogen receptor alpha (ER alpha), oestrogen receptor beta (ER beta), progesterone receptor (PR) and androgen receptor (AR)) show a remarkably similar distribution, although the PR and AR-containing cells are less widespread than oestrogen receptors (ERs). There is considerable overlap in the distribution of ER alpha- and ER beta-containing cells but also some unique sites for each subtype. This suggests differential regulation of the actions of oestrogen. There appears to be little sexual dimorphism in the distribution of the gonadal steroid receptors in the hypothalamus, with the notable exception of the ventromedial nucleus where females appear to have greater numbers of both ER alpha- and ER beta-containing cells. Neuronal tracing studies have identified projections of some of the ER alpha-containing cells to sites that may allow interaction with the GnRH system. The receptor mapping, neuronal tracing and microimplantation studies suggest that the ventromedial nucleus is likely to be a key hypothalamic nucleus in the steroid regulation of GnRH secretion in sheep. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 20:22:26