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Titolo:
Plasma insulin responses after ingestion of different amino acid or protein mixtures with carbohydrate
Autore:
van Loon, LJC; Saris, WHM; Verhagen, H; Wagenmakers, AJM;
Indirizzi:
Maastricht Univ, Dept Human Biol, Nutr & Toxicol Res Inst Maastricht, NL-6200 MD Maastricht, Netherlands Maastricht Univ Maastricht Netherlands NL-6200 MD aastricht, Netherlands TNO, Nutr & Food Res Inst, Food & Non Food Anal Dept, NL-3700 AJ Zeist, Netherlands TNO Zeist Netherlands NL-3700 AJ nal Dept, NL-3700 AJ Zeist, Netherlands
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 1, volume: 72, anno: 2000,
pagine: 96 - 105
SICI:
0002-9165(200007)72:1<96:PIRAIO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-HORMONE; SECRETION; RELEASE; ARGININE; GLUCOSE; GLUTAMINE; EXERCISE; ISLETS;
Keywords:
insulin secretion; amino acid supplementation; protein hydrolysates; leucine; arginine; phenylalanine; glutamine; healthy men;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: van Loon, LJC Maastricht Univ, Dept Human Biol, Nutr & Toxicol Res Inst Maastricht, POB 616, NL-6200 MD Maastricht, Netherlands Maastricht Univ POB 616 Maastricht Netherlands NL-6200 MD s
Citazione:
L.J.C. van Loon et al., "Plasma insulin responses after ingestion of different amino acid or protein mixtures with carbohydrate", AM J CLIN N, 72(1), 2000, pp. 96-105

Abstract

Background: Protein induces an increase in insulin concentrations when ingested in combination with carbohydrate. Increases in plasma insulin concentrations have been observed after the infusion of free amino acids. However,the insulinotropic properties of different amino acids or protein (hydrolysates) when coingested with carbohydrate have not been investigated. Objective: The aim of this study was to define an amino acid and protein (hydrolysate) mixture with a maximal insulinotropic effect when co-ingested with carbohydrate. Design: Eight healthy, nonobese male subjects visited our laboratory, after an overnight fast, on 10 occasions on which different beverage compositions were tested for 2 h. During those trials the subjects ingested 0.8 g kg(-1) . h(-1) carbohydrate and 0.4 g . kg(-1) . h(-1) of an amino acid and protein (hydrolysate) mixture. Results: A strong initial increase in plasma glucose and insulin concentrations was observed in all trials, after which large differences in insulin response between drinks became apparent. After we expressed the insulin response as area under the curve during the second hour, ingestion of the drinks containing free leucine, phenylalanine, and arginine and the drinks withfree leucine, phenylalanine, and wheat protein hydrolysate were followed by the largest insulin response (101% and 103% greater, respectively, than with the carbohydrate-only drink; P < 0.05). Conclusions: Insulin responses are positively correlated with plasma leucine, phenylalanine, and tyrosine concentrations. A mixture of wheat protein hydrolysate, free leucine, phenylalanine, and carbohydrate can be applied as a nutritional supplement to strongly elevate insulin concentrations.

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Documento generato il 01/10/20 alle ore 16:08:05