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Titolo:
Low-fat and high-monounsaturated fatty acid diets decrease plasma cholesterol ester transfer protein concentrations in young, healthy, normolipemic men
Autore:
Jansen, S; Lopez-Miranda, J; Castro, P; Lopez-Segura, F; Marin, C; Ordovas, JM; Paz, F; Jimenez-Pereperez, J; Fuentes, F; Perez-Jimenez, F;
Indirizzi:
Hosp Univ Reina Sofia, Unidad Lipidos & Arteriosclerosis, Cordoba 14004, Spain Hosp Univ Reina Sofia Cordoba Spain 14004 clerosis, Cordoba 14004, Spain Hosp Alto Guadalquivir, Med Interna Serv, Andujar, Spain Hosp Alto Guadalquivir Andujar Spain , Med Interna Serv, Andujar, Spain Hosp Infanta Margarita, Cabra, Spain Hosp Infanta Margarita Cabra SpainHosp Infanta Margarita, Cabra, Spain Tufts Univ, USDA, Human Nutr Res Ctr Aging, Lipid Metab Lab, Boston, MA USA Tufts Univ Boston MA USA Res Ctr Aging, Lipid Metab Lab, Boston, MA USA
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 1, volume: 72, anno: 2000,
pagine: 36 - 41
SICI:
0002-9165(200007)72:1<36:LAHFAD>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN CHOLESTEROL; MESSENGER-RNA LEVELS; TRANSGENIC MICE; OLEIC-ACID; SERUM-LIPIDS; ATHEROSCLEROSIS; DEFICIENCY; METABOLISM; HAMSTERS; INCREASE;
Keywords:
carbohydrates; humans; cholesterol; cholesterol ester transfer protein; CETP; dietary fat; saturated fat; monounsaturated fat; LDL cholesterol; HDL cholesterol; National Cholesterol Education Program Step I diet; Spain; Mediterranean-type diet; men;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Perez-Jimenez, F Hosp Univ Reina Sofia, Unidad Lipidos & Arteriosclerosis,Avda Menendez Pida S-N, Cordoba 14004, Spain Hosp Univ Reina Sofia Avda Menendez Pida S-N Cordoba Spain 14004
Citazione:
S. Jansen et al., "Low-fat and high-monounsaturated fatty acid diets decrease plasma cholesterol ester transfer protein concentrations in young, healthy, normolipemic men", AM J CLIN N, 72(1), 2000, pp. 36-41

Abstract

Background: Cholesterol eater transfer protein (CETP) mediates the transfer of cholesteryl esters from HDL to apolipoprotein (apo) B-containing lipoproteins. The possible atherogenic role of this protein is controversial. Diet may influence plasma CETP concentrations. Objective: The objective was to determine whether the changes in plasma lipids observed after consumption of 2 lipid-lowering diets are associated with changes in plasma CETP concentrations. Design: We studied 41 healthy, normolipidemic men over 3 consecutive 4-wk dietary periods: a saturated fatty acid-rich diet (SFA diet: 38% fat. 20% saturated fat), a National Cholesterol Education Program Step I diet (NCEP Step I diet: 28% fat, 108 saturated fat), and a monounsaturated fatty acid-rich diet (MUFA diet: 38% fat, 22% monounsaturated fat). Cholesterol content(27.5 mg/MJ) was kept constant during the 3 periods. Plasma concentrationsof total, LDL, and HDL cholesterol; triacylglycerol; apo A-I and B; and CETP were measured at the end of each dietary period. Results: Compared with the SFA diet, both lipid-lowering diets significantly decreased plasma total and LDL cholesterol, apo B, and CETP. Only the NCEP Step I diet lowered plasma HDL cholesterol. Positive. significant correlations were found between plasma CETP and total (r = 0.3868, P < 0.0001) and LDL (r = 0.4454, P < 0.0001) cholesterol and also between changes in CETPconcentrations and those of total (r = 0.4543. P < 0.0001) and LDL (r = 0.4554, P < 0.0001) cholesterol. Conclusions: The isoenergetic substitution of a high-saturated fatty acid diet with an NCEP Step I or a high-monounsaturated fatty acid diet decreases plasma CETP concentrations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:34:39