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Titolo:
Brainstem progesterone receptor mRNA upregulation in a rat model of hepatic cirrhosis
Autore:
Abt, PL; Hisatake, GM; Lustik, SJ; Ryan, CK; Flaherty, K; Orloff, MS; Bronsther, OL;
Indirizzi:
Univ Rochester, Strong Mem Hosp, Sch Med & Dent, Dept Surg, Rochester, NY 14642 USA Univ Rochester Rochester NY USA 14642 Dept Surg, Rochester, NY 14642 USA Univ Rochester, Strong Mem Hosp, Sch Med & Dent, Dept Anesthesiol, Rochester, NY 14642 USA Univ Rochester Rochester NY USA 14642 nesthesiol, Rochester, NY 14642 USA Univ Rochester, Strong Mem Hosp, Sch Med & Dent, Dept Pathol, Rochester, NY 14642 USA Univ Rochester Rochester NY USA 14642 ept Pathol, Rochester, NY 14642 USA
Titolo Testata:
ACP-APPLIED CARDIOPULMONARY PATHOPHYSIOLOGY
fascicolo: 1, volume: 9, anno: 2000,
pagine: 33 - 39
SICI:
0920-5268(2000)9:1<33:BPRMUI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER-CIRRHOSIS; GENE-EXPRESSION; HYPERVENTILATION; MECHANISM; ESTRADIOL; FAILURE; DISEASE; ACETATE;
Keywords:
carbon tetrachloride; estradiol; respiratory alkalosis; cirrhosis; progesterone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Abt, PL Univ Rochester, Strong Mem Hosp, Sch Med & Dent, Dept Surg, 601 Elmwood Ave, Rochester, NY 14642 USA Univ Rochester 601 Elmwood Ave RochesterNY USA 14642 NY 14642 USA
Citazione:
P.L. Abt et al., "Brainstem progesterone receptor mRNA upregulation in a rat model of hepatic cirrhosis", APPL CARD P, 9(1), 2000, pp. 33-39

Abstract

Respiratory alkalosis from hyperventilation is seen frequently in patientswith hepatic cirrhosis. Although the etiology is unknown, we previously demonstrated that estradiol and progesterone concentrations correlated with adecreased PaCO2 in cirrhotic patients, suggesting that hormonal changes might stimulate respiratory centers in the brain. The present study explores the possibility that hormonal changes induced by end stage liver disease mediate hyperventilation through the upregulation of brainstem progesterone receptors. Sprague-Dawley rats received CCL4 to induce cirrhosis; control animals were given mineral oil. PaCO2, serum estradiol, and progesterone levels were measured. Cirrhosis was documented by liver biopsy. RT-PCR was usedto determine progesterone receptor mRNA expression. CCL4 treatment resulted in decreased serum progesterone (2.5 ng/mL vs 18.8, P=0.002) and increased estradiol (57.8 +/- 8.47 pg/mL vs 31.9 +/- 6.96, P < 0.001). CCL4 treatedanimals had significantly increased brainstem progesterone receptor expression ratios (0.1502 +/- 0.0637 vs 0.0853 +/- 0.0348, P=0.04). There was no statistically significant decrease in PaCO2 among cirrhotic rats (35.3 vs 39.2, P=0.18). This is the first study to show estradiol induced upregulation of progesterone receptors in the brainstem of cirrhotic animals. Further study is needed to determine if this upregulation is responsible for the hyperventilation common in cirrhotic patients.

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Documento generato il 31/03/20 alle ore 09:19:28