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Titolo:
Fibrous intimal thickening at implantation as a risk factor for the outcome of cadaveric renal allografts
Autore:
Bosmans, JL; Woestenburg, A; Ysebaert, DK; Chapelle, T; Helbert, MJ; Corthouts, R; Jurgens, A; Van Daele, A; Van Marck, EA; De Broe, ME; Verpooten, GA;
Indirizzi:
Univ Antwerp, Dept Nephrol, Antwerp, Belgium Univ Antwerp Antwerp Belgium iv Antwerp, Dept Nephrol, Antwerp, Belgium Univ Antwerp, Dept Transplantat Surg, B-2610 Wilrijk, Belgium Univ Antwerp Wilrijk Belgium B-2610 lantat Surg, B-2610 Wilrijk, Belgium Univ Antwerp, Dept Radiol, B-2610 Wilrijk, Belgium Univ Antwerp Wilrijk Belgium B-2610 Dept Radiol, B-2610 Wilrijk, Belgium Univ Antwerp, Dept Pathol, B-2610 Wilrijk, Belgium Univ Antwerp Wilrijk Belgium B-2610 Dept Pathol, B-2610 Wilrijk, Belgium
Titolo Testata:
TRANSPLANTATION
fascicolo: 11, volume: 69, anno: 2000,
pagine: 2388 - 2394
SICI:
0041-1337(20000615)69:11<2388:FITAIA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELAYED GRAFT FUNCTION; CHRONIC REJECTION; SERUM CREATININE; DONOR AGE; POSTTRANSPLANT FUNCTION; KIDNEY-TRANSPLANTATION; RECIPIENTS; BIOPSIES; SURVIVAL; CYCLOSPORINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Verpooten, GA Univ Antwerp Hosp, Dept Nephrol & Hypertens, Wilrijkstr 10, B-2650 Edegem,Belgium Univ Antwerp Hosp Wilrijkstr 10 Edegem Belgium B-2650 lgium
Citazione:
J.L. Bosmans et al., "Fibrous intimal thickening at implantation as a risk factor for the outcome of cadaveric renal allografts", TRANSPLANT, 69(11), 2000, pp. 2388-2394

Abstract

Background During the past decade, the donor age of cadaveric renal allografts steadily increased, Because cerebrovascular injury is the main cause of death in this donor population, an increased prevalence of atherosclerotic lesions in the retrieved grafts could be anticipated. In a prospective study, we investigated the predictive value of morphologic lesions at implantation for the functional and morphologic outcome of cadaveric renal allografts at 11/2 years. Methods. In 50 consecutive adult recipients of a cadaveric renal allograft, under cyclosporine-based regimen, implantation biopsies and subsequent protocol biopsies at 18 months were performed, and morphometrically analyzed for the extent of glomerulosclerosis, interstitial fibrosis, and atherosclerosis. Risk factors were assessed at implantation and during the subsequentobservation period of 18 months. Endpoints for this study were: the 24-hr creatinine clearance (normalized for body surface area) and the fractional interstitial volume at 11/2 years. Results. In multivariate analysis, fibrous intimal thickening at implantation (FIT) was the main determinant of the functional and morphologic outcome at 11/2 years. FIT represented a relative risk of 4.55 for interstitial fibrosis (95% CI=1.855-11.138), and 1.89 for impaired renal function (95% CI=1.185-3.007) at 11/2 years. FIT adversely affected fractional interstitialvolume at 11/2 years (34.3 vs. 27.7%, P=0.004), as well as renal function (54 vs. 68 ml/min/1.73 m(2), P=0.028). Conclusions. Fibrous intimal thickening at implantation is a determinant risk factor for the functional and morphologic outcome of cadaveric renal allografts at 11/2 years.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:36:32