Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The roles of platelet-activating factor and endothelin-1 in renal damage after total hepatic ischemia and reperfusion
Autore:
Suzuki, S; Serizawa, A; Sakaguchi, T; Tsuchiya, Y; Kojima, Y; Okamoto, K; Kurachi, K; Konno, H; Fujise, Y; Baba, S; Nakamura, S;
Indirizzi:
Hamamatsu Univ, Sch Med, Dept Surg 2, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 , Shizuoka 4313192, Japan Hamamatsu Univ, Sch Med, Dept Chem, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 , Shizuoka 4313192, Japan Hamamatsu Univ, Sch Med, Dept Pathol 2, Hamamatsu, Shizuoka 4313192, JapanHamamatsu Univ Hamamatsu Shizuoka Japan 4313192 , Shizuoka 4313192, Japan
Titolo Testata:
TRANSPLANTATION
fascicolo: 11, volume: 69, anno: 2000,
pagine: 2267 - 2273
SICI:
0041-1337(20000615)69:11<2267:TROPFA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE ORGAN FAILURE; LIVER-TRANSPLANTATION; KUPFFER CELLS; VASOCONSTRICTOR PEPTIDE; PROSTAGLANDIN-I2 ANALOG; NEUTROPHIL ACTIVATION; WARM ISCHEMIA; RAT-LIVER; INJURY; RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, S Hamamatsu Univ, Sch Med, Dept Surg 2, 3600 Handacho, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ 3600 Handacho Hamamatsu Shizuoka Japan 4313192 an
Citazione:
S. Suzuki et al., "The roles of platelet-activating factor and endothelin-1 in renal damage after total hepatic ischemia and reperfusion", TRANSPLANT, 69(11), 2000, pp. 2267-2273

Abstract

Background. This study was designed to verify the involvement of platelet-activating factor (PAF) in renal damage associated with hepatic ischemia and reperfusion (HIR) injury through the release of endothelin (ET)-1 and to determine the modulating effect of a specific PAF receptor antagonist on these insults in rats,Methods. Male rats pretreated with either normal saline as a vehicle (NS group) or intravenous TCV-309, a PAF receptor antagonist (TCV group), were subjected to 120 min of total hepatic ischemia under an extracorporeal portosystemic shunt. Plasma aspartate transaminase, creatinine, blood urea nitrogen, and ET-1 levels and the relative renal wet weight were determined under nonischemic conditions and at 1, 3, and 6 hr of reperfusion after hepaticischemia, Changes in mean arterial blood pressure and renal tissue blood flow measurements in the kidney were determined throughout the experiment. Results, Increased plasma aspartate transaminase, creatinine, blood urea nitrogen, and ET-1 levels and the relative renal wet weight after HIR in theNS group were significantly suppressed by TCV-309 pretreatment. Mean arterial blood pressure and renal tissue blood flow after HIR in the TCV group were significantly improved when compared with those in the NS group, These effects resulted in attenuation of structural hepatic and renal damage withthe improvement of 7-day survival (62%). Conclusions. The present study demonstrates that renal damage as well as critical liver injury is produced after repel fusion following 120 min of total hepatic ischemia, A PAF receptor antagonist may be therapeutically useful to protect against these types of damage via indirect modulation of plasma ET-1 levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/10/20 alle ore 00:10:27