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Titolo:
Supratentorial low-grade glioma: Results and prognostic factors following postoperative radiotherapy
Autore:
Grabenbauer, GG; Roedel, CM; Paulus, W; Ganslandt, O; Schuchardt, U; Buchfelder, M; Schrell, U; Fahlbusch, R; Huk, WJ; Sauer, R;
Indirizzi:
Univ Hosp Erlangen Nurnberg, Dept Radiat Oncol, Erlangen, Germany Univ Hosp Erlangen Nurnberg Erlangen Germany t Oncol, Erlangen, Germany Univ Hosp Erlangen Nurnberg, Dept Neuropathol, Erlangen, Germany Univ HospErlangen Nurnberg Erlangen Germany opathol, Erlangen, Germany Univ Hosp Erlangen Nurnberg, Dept Neurosurg, Erlangen, Germany Univ Hosp Erlangen Nurnberg Erlangen Germany urosurg, Erlangen, Germany Univ Hosp Erlangen Nurnberg, Dept Neuroradiol, Erlangen, Germany Univ HospErlangen Nurnberg Erlangen Germany oradiol, Erlangen, Germany
Titolo Testata:
STRAHLENTHERAPIE UND ONKOLOGIE
fascicolo: 6, volume: 176, anno: 2000,
pagine: 259 - 264
SICI:
0179-7158(200006)176:6<259:SLGRAP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIATION-THERAPY; CEREBRAL ASTROCYTOMAS; RETROSPECTIVE ANALYSIS; PROLIFERATION MARKERS; COGNITIVE FUNCTIONS; RANDOMIZED TRIAL; PATIENT SURVIVAL; LABELING INDEX; ADULTS; MIB-1;
Keywords:
low-grade glioma; radiotherapy; prognostic factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Grabenbauer, GG Univ Erlangen Nurnberg, Klin Strahlentherapie, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 Germany
Citazione:
G.G. Grabenbauer et al., "Supratentorial low-grade glioma: Results and prognostic factors following postoperative radiotherapy", STRAH ONKOL, 176(6), 2000, pp. 259-264

Abstract

Background and Purpose: To assess treatment outcome and prognostic factorsfollowing postoperative external radiotherapy in 77 patients with low-grade glioma. Patients and Methods: Between 1977 and 1996, 45 patients with astrocytoma,14 with oligodendroglioma and 18 with mixed glioma received postoperative radiotherapy with a median total dose of 52 Gy (range, 45 to 61 Gy). Sixty-seven patients were treated immediately following surgery, 10 patients withtumor progression. The influence of various factors including histology, gender, age, seizures, duration of symptoms (less than or equal to 6 weeks vs > 6 weeks), CT pattern (enhancement vs no enhancement), type of surgery, total radiotherapy dose and timing of radiotherapy on relapse-free survivaland overall survival was investigated. Results: The median overall survival time was 81 months, the 5- and 10-year survival rates were 54% and 31%, respectively. The median time to progression was 56 months, while the 5- and 10-year progression-free survival rates were 45% and 24%. Univariate analyses identified the total radiotherapy dose (p = 0.01), duration of symptoms (p = 0.05), the presence of seizures (p = 0.04), and the CT pattern following intravenous contrast (p = 0.005) assignificant prognostic factors for overall survival. Progression-free survival rates were influenced by the total dose (p = 0.04), the duration of symptoms (p = 0.01) and CT pattern (p = 0.006). On multivariate analysis, only the CT pattern (enhancement vs no enhancement) remained as independent prognostic factors for both progression-free survival and overall survival. Conclusion: A minimum total dose of 52 Gy is recommended for the postoperative radiotherapy in low-grade glioma. Tumors with CT enhancement seem to need further intensification of treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:50:00